Dario J Englot1, Anthony T Lee, Catherine Tsai, Cathra Halabi, Nicholas M Barbaro, Kurtis I Auguste, Paul A Garcia, Edward F Chang. 1. *UCSF Epilepsy Center, University of California, San Francisco, California; ‡Department of Neurological Surgery, University of California, San Francisco, California; §Department of Neurology, University of California, San Francisco, California; ¶Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana; ||Children's Hospital and Research Center Oakland, Oakland, California.
Abstract
BACKGROUND: Temporal lobectomy can lead to favorable seizure outcomes in medically-refractory temporal lobe epilepsy (TLE). Although most studies focus on seizure freedom after temporal lobectomy, less is known about seizure semiology in patients who "fail" surgery. Morbidity differs between seizure types that impair or spare consciousness. Among TLE patients with seizures after surgery, how does temporal lobectomy influence seizure type and frequency? OBJECTIVE: To characterize seizure types and frequencies before and after temporal lobectomy for TLE, including consciousness-sparing or consciousness-impairing seizures. METHODS: We performed a retrospective longitudinal cohort study examining patients undergoing temporal lobectomy for epilepsy at our institution from January 1995 to August 2010. RESULTS: Among 241 TLE patients who received temporal lobectomy, 174 (72.2%) patients achieved Engel class I outcome (free of disabling seizures), including 141 (58.5%) with complete seizure freedom. Overall seizure frequency in patients with persistent postoperative seizures decreased by 70% (P < .01), with larger reductions in consciousness-impairing seizures. While the number of patients experiencing consciousness-sparing simple partial seizures decreased by only 19% after surgery, the number of individuals having consciousness-impairing complex partial seizures and generalized tonic-clonic seizures diminished by 70% and 68%, respectively (P < .001). Simple partial seizure was the predominant seizure type in 19.1% vs 37.0% of patients preoperatively and postoperatively, respectively (P < .001). Favorable seizure outcome was predicted by a lack of generalized seizures preoperatively (odds ratio 1.74, 95% confidence interval 1.06-2.86, P < .5). CONCLUSION: Given important clinical and mechanistic differences between seizures with or without impairment of consciousness, seizure type and frequency remain important considerations in epilepsy surgery.
BACKGROUND: Temporal lobectomy can lead to favorable seizure outcomes in medically-refractory temporal lobe epilepsy (TLE). Although most studies focus on seizure freedom after temporal lobectomy, less is known about seizure semiology in patients who "fail" surgery. Morbidity differs between seizure types that impair or spare consciousness. Among TLEpatients with seizures after surgery, how does temporal lobectomy influence seizure type and frequency? OBJECTIVE: To characterize seizure types and frequencies before and after temporal lobectomy for TLE, including consciousness-sparing or consciousness-impairing seizures. METHODS: We performed a retrospective longitudinal cohort study examining patients undergoing temporal lobectomy for epilepsy at our institution from January 1995 to August 2010. RESULTS: Among 241 TLEpatients who received temporal lobectomy, 174 (72.2%) patients achieved Engel class I outcome (free of disabling seizures), including 141 (58.5%) with complete seizure freedom. Overall seizure frequency in patients with persistent postoperative seizures decreased by 70% (P < .01), with larger reductions in consciousness-impairing seizures. While the number of patients experiencing consciousness-sparing simple partial seizures decreased by only 19% after surgery, the number of individuals having consciousness-impairing complex partial seizures and generalized tonic-clonic seizures diminished by 70% and 68%, respectively (P < .001). Simple partial seizure was the predominant seizure type in 19.1% vs 37.0% of patients preoperatively and postoperatively, respectively (P < .001). Favorable seizure outcome was predicted by a lack of generalized seizures preoperatively (odds ratio 1.74, 95% confidence interval 1.06-2.86, P < .5). CONCLUSION: Given important clinical and mechanistic differences between seizures with or without impairment of consciousness, seizure type and frequency remain important considerations in epilepsy surgery.
Authors: Dario J Englot; Seunggu J Han; John D Rolston; Michael E Ivan; Rachel A Kuperman; Edward F Chang; Nalin Gupta; Joseph E Sullivan; Kurtis I Auguste Journal: J Neurosurg Pediatr Date: 2014-08-15 Impact factor: 2.375
Authors: Dario J Englot; Srikantan S Nagarajan; Brandon S Imber; Kunal P Raygor; Susanne M Honma; Danielle Mizuiri; Mary Mantle; Robert C Knowlton; Heidi E Kirsch; Edward F Chang Journal: Epilepsia Date: 2015-04-29 Impact factor: 5.864
Authors: Dario J Englot; Kunal P Raygor; Annette M Molinaro; Paul A Garcia; Robert C Knowlton; Kurtis I Auguste; Edward F Chang Journal: Neurosurgery Date: 2014-12 Impact factor: 4.654
Authors: Dario J Englot; Srikantan S Nagarajan; Doris D Wang; John D Rolston; Danielle Mizuiri; Susanne M Honma; Mary Mantle; Phiroz E Tarapore; Robert C Knowlton; Edward F Chang; Heidi E Kirsch Journal: Epilepsy Res Date: 2016-01-29 Impact factor: 3.045
Authors: Max O Krucoff; Alvin Y Chan; Stephen C Harward; Shervin Rahimpour; John D Rolston; Carrie Muh; Dario J Englot Journal: Epilepsia Date: 2017-10-10 Impact factor: 5.864