| Literature DB >> 23892082 |
Akio Nakashima1, Keiko Tanimura-Ito, Noriko Oshiro, Satoshi Eguchi, Takafumi Miyamoto, Ayaka Momonami, Shinji Kamada, Kazuyoshi Yonezawa, Ushio Kikkawa.
Abstract
Target of rapamycin complex 1 (TORC1) has a key role in cellular regulations in response to environmental conditions. In yeast, Tip41 downregulates TORC1 signaling via activation of PP2A phosphatase. We show here that overexpression of TIPRL, a mammalian Tip41, suppressed dephosphorylation of mechanistic TORC1 (mTORC1) substrates under amino acid withdrawal, and knockdown of TIPRL conversely attenuated phosphorylation of those substrates after amino acid refeeding. TIPRL associated with the catalytic subunit of PP2A (PP2Ac), which was required for the TIPRL action on mTORC1 signaling. Collectively, unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac.Entities:
Keywords: 4E-BP1; Amino acid; HA; HCC; PP2A; PP2A catalytic subunit; PP2Ac; S6K1; TIPRL; TOR; TOR complex; TORC; TRAIL; Tap42; Tap42-interacting protein of 41kDa; Tip41; eIF4E-binding protein 1; hemagglutinin; hepatocellular carcinoma; mTOR; mTORC1; mechanistic TOR; p70 ribosomal protein S6 kinase 1; protein phosphatase 2A; siRNA; small interfering RNA; target of rapamycin; target of rapamycin signaling pathway regulator-like; tumor necrosis factor-related apoptosis-inducing ligand; type 2A phosphatase-associated protein of 42kDa
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Year: 2013 PMID： 23892082 DOI： 10.1016/j.febslet.2013.07.027
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124