Literature DB >> 23892

Histopathology of veins after intravenous lorazepam and RO 21-3981.

R R Pagano, C W Graham, M Galligan, J T Conner, R L Katz.   

Abstract

A previously established rat model has been utilized to demonstrate that an acute inflammatory response occurs after high intravenous doses of lorazepam. This occurs only with high concentrations of drug equivalent to 20 times the normal clinical dosage in man. In contract, water soluble RO 21-3981 produces no vascular pathology in any dosage evaluated. It appears that propylene glycol may play a role in the pathogenesis of the intravascular injury observed.

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Year:  1978        PMID： 23892     DOI： 10.1007/BF03006784

Source DB:  PubMed          Journal:  Can Anaesth Soc J        ISSN： 0008-2856


  3 in total

1.  Pathogenesis of gangrene following intra-arterial injection of drugs: a new hypothesis.

Authors:  R L Knill; D Evans
Journal:  Can Anaesth Soc J       Date:  1975-11

2.  Thrombophlebitis with diazepam used intravenously.

Authors:  D E Langdon; J R Harlan; R L Bailey
Journal:  JAMA       Date:  1973-01-08       Impact factor: 56.272

3.  Thrombophlebitis after intravenous diazepam--can it be prevented?

Authors:  C W Graham; R R Pagano; R L Katz
Journal:  Anesth Analg       Date:  1977 May-Jun       Impact factor: 5.108
  3 in total
  6 in total

1.  Midazolam compared with thiopentone as a hypnotic component in balanced anaesthesia: a randomized, double-blind study.

Authors:  J G Reves; R Vinik; A M Hirschfield; C Holcomb; S Strong
Journal:  Can Anaesth Soc J       Date:  1979-01

Review 2.  Midazolam: review of a versatile agent for use in dentistry.

Authors:  J A Giovannitti
Journal:  Anesth Prog       Date:  1987 Sep-Oct

3.  Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in ill surgical patients.

Authors:  P W Lebowitz; M E Cote; A L Daniels; J A Martyn; R S Teplick; J K Davison; N Sunder
Journal:  Can Anaesth Soc J       Date:  1983-01

4.  Incidence of thrombophlebitis in humans with the diazepam vehicle.

Authors:  R B Parkes; P L Blanton; W J Thrash
Journal:  Anesth Prog       Date:  1982 Nov-Dec

Review 5.  Midazolam. A review of its pharmacological properties and therapeutic use.

Authors:  J W Dundee; N J Halliday; K W Harper; R N Brogden
Journal:  Drugs       Date:  1984-12       Impact factor: 9.546

6.  Use of midazolam for percutaneous liver biopsy.

Authors:  D E Brouillette; Y K Yoo; M C Chien; M Rabinovitz; R E Tarter; D H Van Thiel
Journal:  Dig Dis Sci       Date:  1989-10       Impact factor: 3.199
  6 in total

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