| Literature DB >> 23891820 |
Jun Wang1, Xufeng Guo, Pengbo Wu, Jia Song, Chuncui Ye, Shijie Yu, Jixiang Zhang, Weiguo Dong.
Abstract
Several studies have been conducted to examine the association between PPAR-γ2 Pro12Ala polymorphism and non-alcoholic fatty liver disease (NAFLD), but the results remain inconsistent. In this study, a meta-analysis was performed to assess the association of PPAR-γ Pro12Ala polymorphism with NAFLD risk. A total of 8 case-control studies, including 1697 cases and 2427 controls, were selected. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Overall, no evidence has indicated that the Pro12Ala polymorphism was associated with the susceptibility to NAFLD. Besides, stratified analysis with ethnicity also indicated that no significant association between PPAR-γ Pro12Ala and the risk of NAFLD under all for genetic model in both Asian and Caucasian populations was observed. This meta-analysis indicated that the Pro12Ala polymorphism is not associated with NAFLD risk. Large and well-designed studies are warranted to validate our findings.Entities:
Keywords: CI; HWE; Hardy–Weinberg equilibrium; MS; Meta-analysis; NAFLD; NASH; Non-alcoholic fatty liver disease; OR; PPAR-γ; Polymorphism; SNP; confidence interval; metabolic syndrome; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; odds ratio; peroxisome proliferator activated receptor-γ; single nucleotide polymorphism
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Year: 2013 PMID： 23891820 DOI： 10.1016/j.gene.2013.07.014
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688