OBJECTIVES: Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and FAM13A polymorphisms in non-Asian populations. The aim of this study was to investigate whether FAM13A polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in a Chinese Han population. METHODS: Seven single nucleotide polymorphisms (SNPs) (rs7671167, rs10007590, rs2869966, rs2869967, rs2045517, rs1903003, rs6830970) in FAM13A gene were genotyped in a case-control study (680 COPD patients and 687 controls). Allele frequencies and genotype distributions were compared between patients and controls. To estimate the strength of association, odds ratios (OR) (with 95% CI) were calculated and potential confounding variables were tested by using logistic regression analysis. RESULTS: Statistical analysis revealed that SNP rs7671167 was associated with COPD in former smokers with adjusted P-value of 0.026. Five SNPs (rs7671167, rs2869966, rs2869967, rs2045517, and rs6830970) were associated with FEV1/FVC ratio in the entire cohort and rs6830970 was associated with FEV1/FVC ratio in COPD cases (P range 0.003-0.034). Borderline associations with FEV1/FVC ratio were found for rs2869966, rs2869967 and rs2045517 among cases (P=0.05). Six SNPs (rs7671167, rs2869966, rs2869967, rs2045517, rs1903003, rs6830970) showed strong linkage disequilibrium (r(2) ≥ 0.9). Four major haplotypes were observed but showed no significant difference between case and control groups (P=0.2356, 0.1273, 0.6266 and 0.3006 respectively). CONCLUSIONS: The current study suggests that the FAM13A locus might be a contributor to COPD susceptibility in Chinese Han population.
OBJECTIVES: Genome-wide association studies (GWAS) and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and FAM13A polymorphisms in non-Asian populations. The aim of this study was to investigate whether FAM13A polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in a Chinese Han population. METHODS: Seven single nucleotide polymorphisms (SNPs) (rs7671167, rs10007590, rs2869966, rs2869967, rs2045517, rs1903003, rs6830970) in FAM13A gene were genotyped in a case-control study (680 COPDpatients and 687 controls). Allele frequencies and genotype distributions were compared between patients and controls. To estimate the strength of association, odds ratios (OR) (with 95% CI) were calculated and potential confounding variables were tested by using logistic regression analysis. RESULTS: Statistical analysis revealed that SNP rs7671167 was associated with COPD in former smokers with adjusted P-value of 0.026. Five SNPs (rs7671167, rs2869966, rs2869967, rs2045517, and rs6830970) were associated with FEV1/FVC ratio in the entire cohort and rs6830970 was associated with FEV1/FVC ratio in COPD cases (P range 0.003-0.034). Borderline associations with FEV1/FVC ratio were found for rs2869966, rs2869967 and rs2045517 among cases (P=0.05). Six SNPs (rs7671167, rs2869966, rs2869967, rs2045517, rs1903003, rs6830970) showed strong linkage disequilibrium (r(2) ≥ 0.9). Four major haplotypes were observed but showed no significant difference between case and control groups (P=0.2356, 0.1273, 0.6266 and 0.3006 respectively). CONCLUSIONS: The current study suggests that the FAM13A locus might be a contributor to COPD susceptibility in Chinese Han population.
Authors: Wei Chen; John M Brehm; Ani Manichaikul; Michael H Cho; Nadia Boutaoui; Qi Yan; Kristin M Burkart; Paul L Enright; Jerome I Rotter; Hans Petersen; Shuguang Leng; Ma'en Obeidat; Yohan Bossé; Corry-Anke Brandsma; Ke Hao; Stephen S Rich; Rhea Powell; Lydiana Avila; Manuel Soto-Quiros; Edwin K Silverman; Yohannes Tesfaigzi; R Graham Barr; Juan C Celedón Journal: Ann Am Thorac Soc Date: 2015-03
Authors: Iwona Ziółkowska-Suchanek; Maria Mosor; Piotr Gabryel; Marcin Grabicki; Magdalena Żurawek; Marta Fichna; Ewa Strauss; Halina Batura-Gabryel; Wojciech Dyszkiewicz; Jerzy Nowak Journal: Sci Rep Date: 2015-08-27 Impact factor: 4.379
Authors: Zili Zhang; Jian Wang; Zeguang Zheng; Xindong Chen; Xiansheng Zeng; Yi Zhang; Defu Li; Jiaze Shu; Kai Yang; Ning Lai; Lian Dong; Wenju Lu Journal: Biomed Res Int Date: 2017-08-27 Impact factor: 3.411