Raúl de la Fuente-Fernández1. 1. Section of Neurology, Complejo Hospitalario Universitario de Ferrol (CHUF), Hospital A. Marcide, 15405 Ferrol, Spain. Electronic address: rfuente@medynet.com.
Abstract
OBJECTIVE: To investigate whether Parkinson's disease (PD) and dementia are competing risks in subjects with idiopathic rapid-eye-movement sleep behavior disorder (RBD). METHODS: The number of incidental PD cases observed in 11 longitudinal RBD studies was compared with the corresponding expected number as estimated by a simple mathematical model based on population parameters for PD age-of-onset. RESULTS: The expected number of incidental PD cases exceeded observed PD cases (p-value < 0.001) but was in agreement with the sum of observed PD cases and observed mild cognitive impairment/dementia cases (p-value = 0.34). Sensitivity analyses confirmed the results. CONCLUSION: In the RBD population, PD and dementia cases are competing risks, suggesting that alpha-synuclein pathology occurs simultaneously in substantia nigra and neocortex. This observation has implications for the design and analysis of trials of neuroprotection.
OBJECTIVE: To investigate whether Parkinson's disease (PD) and dementia are competing risks in subjects with idiopathic rapid-eye-movement sleep behavior disorder (RBD). METHODS: The number of incidental PD cases observed in 11 longitudinal RBD studies was compared with the corresponding expected number as estimated by a simple mathematical model based on population parameters for PD age-of-onset. RESULTS: The expected number of incidental PD cases exceeded observed PD cases (p-value < 0.001) but was in agreement with the sum of observed PD cases and observed mild cognitive impairment/dementia cases (p-value = 0.34). Sensitivity analyses confirmed the results. CONCLUSION: In the RBD population, PD and dementia cases are competing risks, suggesting that alpha-synuclein pathology occurs simultaneously in substantia nigra and neocortex. This observation has implications for the design and analysis of trials of neuroprotection.
Authors: Lama M Chahine; Shilpa R Kauta; Joseph T Daley; Charles R Cantor; Nabila Dahodwala Journal: Parkinsonism Relat Disord Date: 2014-04-18 Impact factor: 4.891
Authors: Petr Dušek; Veronika Lorenzo Y Losada Ibarburu; Ondrej Bezdicek; Irene Dall'antonia; Simona Dostálová; Petra Kovalská; Radim Krupička; Jiří Nepožitek; Tomáš Nikolai; Michal Novotný; Pavla Peřinová; Jan Rusz; Tereza Serranová; Tereza Tykalová; Olga Ulmanová; Zuzana Mecková; Václav Ptáčník; Jiří Trnka; David Zogala; Evžen Růžička; Karel Šonka Journal: Sci Rep Date: 2019-10-29 Impact factor: 4.379