| Literature DB >> 23891231 |
Ayşe Selcen Alpan1, Sülünay Parlar, Luca Carlino, Ayse Hande Tarikogullari, Vildan Alptüzün, Hasan Semih Güneş.
Abstract
A series of N-{2-[4-(1H-benzimidazole-2-yl)phenoxy]ethyl}substituted amine derivatives were designed to assess cholinesterase inhibitor activities. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor activities were evaluated in vitro by using Ellman's method. It was discovered that most of the compounds displayed AChE and/or BuChE inhibitor activity and few compounds were selective against AChE/BuChE. Compound 3c and 3e were the most active compounds in the series against eeAChE and hAChE, respectively. Molecular docking studies and molecular dynamics simulations were also carried out.Entities:
Keywords: 1H-Benzimidazole; 5,5′-dithiobis(2-nitrobenzoic acid); AChE; AChEI; AD; ATC; Acetylcholinesterase inhibitor; Alzheimer’s disease; Aβ; BuChE; Butyrylcholinesterase inhibitor; CAS; DTNB; Electrophorus electricus AChE; MD; Molecular modeling; PAS; RMSD; Synthesis; TcAChE; Torpedo californica AChE; acetylcholinesterase; acetylcholinesterase inhibitors; acetylthiocholine iodide; butyrylcholinesterase; catalytic active site; eeAChE; hAChE; human AChE; molecular dynamics; peripheral anionic site; root mean square deviation; β-amyloid
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Year: 2013 PMID： 23891231 DOI： 10.1016/j.bmc.2013.06.065
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641