Literature DB >> 23890819

Just a trim, please: refining ER degradation through deubiquitination.

Jeffrey L Brodsky1.   

Abstract

ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23890819      PMCID： PMC5423715          DOI： 10.1016/j.cell.2013.07.008

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation.

Authors:  R G Gardner; A G Shearer; R Y Hampton
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

Review 2.  The ubiquitin system, an immense realm.

Authors:  Alexander Varshavsky
Journal:  Annu Rev Biochem       Date:  2012       Impact factor: 23.643

Review 3.  Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

Authors:  Francisca E Reyes-Turcu; Karen H Ventii; Keith D Wilkinson
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

Review 4.  Role of HIV-1 Vpu protein for virus spread and pathogenesis.

Authors:  Masako Nomaguchi; Mikako Fujita; Akio Adachi
Journal:  Microbes Infect       Date:  2008-07-10       Impact factor: 2.700

5.  A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells.

Authors:  Sumana Sanyal; Jasper H L Claessen; Hidde L Ploegh
Journal:  J Biol Chem       Date:  2012-05-22       Impact factor: 5.157

6.  The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation.

Authors:  G C Meacham; C Patterson; W Zhang; J M Younger; D M Cyr
Journal:  Nat Cell Biol       Date:  2001-01       Impact factor: 28.824

7.  Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein.

Authors:  Shuhei Ishikura; Allan M Weissman; Juan S Bonifacino
Journal:  J Biol Chem       Date:  2010-06-02       Impact factor: 5.157

8.  Defining the human deubiquitinating enzyme interaction landscape.

Authors:  Mathew E Sowa; Eric J Bennett; Steven P Gygi; J Wade Harper
Journal:  Cell       Date:  2009-07-16       Impact factor: 41.582

Review 9.  One step at a time: endoplasmic reticulum-associated degradation.

Authors:  Shruthi S Vembar; Jeffrey L Brodsky
Journal:  Nat Rev Mol Cell Biol       Date:  2008-11-12       Impact factor: 94.444

10.  Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.

Authors:  Zai-Rong Zhang; Juan S Bonifacino; Ramanujan S Hegde
Journal:  Cell       Date:  2013-07-25       Impact factor: 41.582
  10 in total
  2 in total

1.  Binding of SGTA to Rpn13 selectively modulates protein quality control.

Authors:  Pawel Leznicki; Jelena Korac-Prlic; Katarzyna Kliza; Koraljka Husnjak; Yvonne Nyathi; Ivan Dikic; Stephen High
Journal:  J Cell Sci       Date:  2015-07-13       Impact factor: 5.285

2.  The threads that tie protein-folding diseases.

Authors:  Jeffrey L Brodsky
Journal:  Dis Model Mech       Date:  2014-01       Impact factor: 5.758
  2 in total

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