Li Chang1, Xiaojuan Liu1, Hua Shi1, Wei Dai1, Hong Wang1, Yongmei Jiang1. 1. Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No. 20, Section 3, Ren Min Nan Lu, Chengdu, Sichuan 610041, People's Republic of China.
Abstract
OBJECTIVE: To evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China. DESIGN: A cross-sectional and 1-year retrospective study. SETTING: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China. SUBJECTS: Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011). RESULTS: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33.18 (sd 16.48) ng/ml) was deficient in 21.6% and insufficient in 27.4%, which were higher than the prevalence of both anaemia at 8.5% and elevated BLL (Pb ≥ 10 μg/dl) at 1.8%, but lower than mildly elevated BLL prevalence (5 μg/dl ≤ Pb < 10 μg/dl) at 56.9%. There was a negative correlation between 25(OH)D concentration and BLL (r = -0.216, P < 0.001) while no significant relationship was found between 25(OH)D concentration and Hb (r = -0.012, P > 0.05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR = 18.29; 95% CI 10.14, 32.99; P < 0.001) and BLL (OR = 1.01; 95% CI 1.00, 1.02; P = 0.045). CONCLUSIONS: The prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.
OBJECTIVE: To evaluate the prevalence of vitamin Ddeficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China. DESIGN: A cross-sectional and 1-year retrospective study. SETTING: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China. SUBJECTS:Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011). RESULTS: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33.18 (sd 16.48) ng/ml) was deficient in 21.6% and insufficient in 27.4%, which were higher than the prevalence of both anaemia at 8.5% and elevated BLL (Pb ≥ 10 μg/dl) at 1.8%, but lower than mildly elevated BLL prevalence (5 μg/dl ≤ Pb < 10 μg/dl) at 56.9%. There was a negative correlation between 25(OH)D concentration and BLL (r = -0.216, P < 0.001) while no significant relationship was found between 25(OH)D concentration and Hb (r = -0.012, P > 0.05). After multivariable adjustment, the significant predictors of 25(OH)Ddeficiency and insufficiency were increasing child age especially between 8 and 14 years (OR = 18.29; 95% CI 10.14, 32.99; P < 0.001) and BLL (OR = 1.01; 95% CI 1.00, 1.02; P = 0.045). CONCLUSIONS: The prevalence of 25(OH)Ddeficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.