Literature DB >> 2388975

Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing.

J G Csernansky1, E P Bellows, D E Barnes, L Lombrozo.   

Abstract

Recent clinical research suggests that particular patterns of changes in presynaptic dopamine (DA) turnover accompany the therapeutic response to neuroleptics. We sought to determine whether daily versus weekly dosing of haloperidol for 3 weeks produced distinct effects on DA, dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) concentrations in multiple brain areas. Daily dosing favored the development of tolerance to the DA-turnover elevating effects of haloperidol in the striatum and nucleus accumbens. Weekly dosing favored the development of sensitization in the striatum, posterior olfactory tubercle, and ventral tegmental area. These results suggest that dosing schedules may determine, at least in part, the effects of chronic neuroleptic administration on presynaptic DA function.

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Year:  1990        PMID： 2388975     DOI： 10.1007/bf02244231

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  33 in total

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Authors:  R Strong
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Authors:  S K Puri; H Lal
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4.  Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation.

Authors:  G Blanc; D Hervé; H Simon; A Lisoprawski; J Glowinski; J P Tassin
Journal:  Nature       Date:  1980-03-20       Impact factor: 49.962

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Authors:  E S Prosser; R Pruthi; J G Csernansky
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

6.  Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration.

Authors:  M B Bowers; F J Hoffman
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

7.  Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine.

Authors:  A C Sayers; H R Bürki; W Ruch; H Asper
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Authors:  M B Bowers; M E Swigar; P I Jatlow; N Goicoechea
Journal:  J Clin Psychiatry       Date:  1984-06       Impact factor: 4.384

9.  Quinpirole hydrochloride, a potential anti-parkinsonism drug.

Authors:  W Koller; G Herbster; D Anderson; R Wack; J Gordon
Journal:  Neuropharmacology       Date:  1987-08       Impact factor: 5.250

10.  Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Correlation with psychosis and response to neuroleptic treatment.

Authors:  D Pickar; R Labarca; A R Doran; O M Wolkowitz; A Roy; A Breier; M Linnoila; S M Paul
Journal:  Arch Gen Psychiatry       Date:  1986-07
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Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

3.  Subcortical dopamine and serotonin turnover during acute and subchronic administration of typical and atypical neuroleptics.

Authors:  J G Csernansky; C T Wrona; M E Bardgett; T S Early; J W Newcomer
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4.  Interactions between chronic haloperidol treatment and cocaine in rats: an animal model of intermittent cocaine use in neuroleptic treated populations.

Authors:  P A LeDuc; G Mittleman
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

5.  Sensitization to haloperidol-induced suppression of milk intake: effect of interdose interval.

Authors:  D L Wolgin; J Moore
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

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Journal:  Neuroscience       Date:  2013-05-30       Impact factor: 3.590

Review 8.  Schizophrenia and psychostimulant abuse: a review and re-analysis of clinical evidence.

Authors:  P A LeDuc; G Mittleman
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530

9.  Poor evidence for depolarization block but uncoupling of nigral from striatal dopamine metabolism after chronic haloperidol treatment in the rat.

Authors:  S J Chrapusta; M F Egan
Journal:  J Neural Transm (Vienna)       Date:  2005-08-05       Impact factor: 3.850
  9 in total

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