BACKGROUND: Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. METHODS: In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. RESULTS: Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). CONCLUSIONS: We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.
BACKGROUND: Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. METHODS: In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. RESULTS: Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). CONCLUSIONS: We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.
Authors: Toru Takahashi; Atsushi Kato; Sergejs Berdnikovs; Whitney W Stevens; Lydia A Suh; James E Norton; Roderick G Carter; Kathleen E Harris; Anju T Peters; Kathryn E Hulse; Leslie C Grammer; Kevin C Welch; Stephanie Shintani-Smith; Bruce K Tan; David B Conley; Robert C Kern; Bruce S Bochner; Robert P Schleimer Journal: J Allergy Clin Immunol Date: 2017-02-24 Impact factor: 10.793
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