| Literature DB >> 23888309 |
Dong Yang1, Mei Jiang, Min Jin, Zhigang Qiu, Weihong Cui, Zhiqiang Shen, Bo Li, Lianfeng Gong, Zhaoli Chen, Xinwei Wang, Jun-Wen Li.
Abstract
The complete genome sequence of a genotype 4 strain of hepatitis E virus (CH-YT-HEV02) from a patient (in Yantai, China) has been determined. Phylogenetic analysis showed that CH-YT-HEV02 belongs to genotype 4, subtype 4a. However, the phylogenetic analysis indicated that it was most closely related to JKO-CHiSai98C (AB197673) strain, sharing only 91.6% sequence identity with it. Judging from the phylogenetic tree based on the full-length nucleotide sequences of all 70 genotype 4 HEV isolates retrieved from GenBank up to May, 2013, the CH-YT-HEV02 isolates could serve as a Yantai-indigenous strain. A broader comparison with other genotype isolates revealed that there are a few conserved amino acids in the HVR region of different HEV genotypes, and two amino acid motifs in ORF2 and ORF3 might serve as signatures of genotype diversity of HEV.Entities:
Mesh：
Year: 2013 PMID： 23888309 DOI： 10.1007/s11262-013-0962-7
Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332