BACKGROUND: The occurrence of severe neonatal hyperbilirubinemia (SH) is partly attributed to nonhospitalized perinatal care. The Netherlands have a high frequency of home births and nonhospitalized perinatal care, and the incidence of SH is unknown. OBJECTIVE: To assess the effects of home births and early hospital discharge on the incidence of SH in term-born infants in the Netherlands. METHODS: In this nationwide prospective surveillance study between 2005 and 2009, infants (≥37 weeks GA) were included if total serum bilirubin (TSB) was ≥500 µmol/l or if they received an exchange transfusion when TSB was ≥340 µmol/l. RESULTS: Seventy-one infants had SH (incidence 10.4/100,000); 43 had a TSB ≥500 μmol/l (incidence 6.3/100,000) and 45 (63%) underwent an exchange transfusion. 26% of the infants with SH were born at home, which is similar to 22% of all term infants who are born at home in the Netherlands (p = 0.41). Maximum TSB levels were similar in infants born at home (523 ± 114 μmol/l) and infants born in hospital (510 ± 123 μmol/l; p = 0.70). Of the 51 infants born in hospital, 33 were discharged and readmitted with SH, with maximal TSB levels (567 ± 114 μmol/l), which were higher than in infants who remained hospitalized (406 ± 47 μmol/l; p = 0.0001). CONCLUSION: The incidence of severe hyperbilirubinemia in term-born infants in the Netherlands is 10.4 per 100,000, which is similar to other developed countries. Home birth and early hospital discharge do not necessarily lead to a higher incidence of SH, provided that perinatal home care is well organized.
BACKGROUND: The occurrence of severe neonatal hyperbilirubinemia (SH) is partly attributed to nonhospitalized perinatal care. The Netherlands have a high frequency of home births and nonhospitalized perinatal care, and the incidence of SH is unknown. OBJECTIVE: To assess the effects of home births and early hospital discharge on the incidence of SH in term-born infants in the Netherlands. METHODS: In this nationwide prospective surveillance study between 2005 and 2009, infants (≥37 weeks GA) were included if total serum bilirubin (TSB) was ≥500 µmol/l or if they received an exchange transfusion when TSB was ≥340 µmol/l. RESULTS: Seventy-one infants had SH (incidence 10.4/100,000); 43 had a TSB ≥500 μmol/l (incidence 6.3/100,000) and 45 (63%) underwent an exchange transfusion. 26% of the infants with SH were born at home, which is similar to 22% of all term infants who are born at home in the Netherlands (p = 0.41). Maximum TSB levels were similar in infants born at home (523 ± 114 μmol/l) and infants born in hospital (510 ± 123 μmol/l; p = 0.70). Of the 51 infants born in hospital, 33 were discharged and readmitted with SH, with maximal TSB levels (567 ± 114 μmol/l), which were higher than in infants who remained hospitalized (406 ± 47 μmol/l; p = 0.0001). CONCLUSION: The incidence of severe hyperbilirubinemia in term-born infants in the Netherlands is 10.4 per 100,000, which is similar to other developed countries. Home birth and early hospital discharge do not necessarily lead to a higher incidence of SH, provided that perinatal home care is well organized.
Authors: C Greco; I F Iskander; D M Akmal; S Z El Houchi; D A Khairy; G Bedogni; R P Wennberg; C Tiribelli; C D Coda Zabetta Journal: J Perinatol Date: 2017-06-15 Impact factor: 2.521
Authors: Amy R Borden; Katie M Satrom; Paul Wratkowski; Thomas N George; Constance A Adkisson; Hendrik J Vreman; Austin P Johnson; Kent J Nichols; Tina M Slusher Journal: Neonatology Date: 2018-01-31 Impact factor: 4.035
Authors: Berthe A M van der Geest; Johanna P de Graaf; Loes C M Bertens; Marten J Poley; Erwin Ista; René F Kornelisse; Irwin K M Reiss; Eric A P Steegers; Jasper V Been Journal: BMJ Open Date: 2019-04-20 Impact factor: 2.692
Authors: Berthe A M van der Geest; Malou J S de Mol; Ivana S A Barendse; Johanna P de Graaf; Loes C M Bertens; Marten J Poley; Erwin Ista; René F Kornelisse; Irwin K M Reiss; Eric A P Steegers; Jasper V Been Journal: Sci Rep Date: 2022-08-23 Impact factor: 4.996
Authors: Tina M Slusher; Tara G Zamora; Duke Appiah; Judith U Stanke; Mark A Strand; Burton W Lee; Shane B Richardson; Elizabeth M Keating; Ashajoythi M Siddappa; Bolajoko O Olusanya Journal: BMJ Paediatr Open Date: 2017-11-25