Literature DB >> 23886951

cDNA cloning and structural characterization of a lectin from the mussel Crenomytilus grayanus with a unique amino acid sequence and antibacterial activity.

Svetlana N Kovalchuk1, Irina V Chikalovets, Oleg V Chernikov, Valentina I Molchanova, Wei Li, Valery A Rasskazov, Pavel A Lukyanov.   

Abstract

An amino acid sequence of GalNAc/Gal-specific lectin from the mussel Crenomytilus grayanus (CGL) was determined by cDNA sequencing. CGL consists of 150 amino acid residues, contains three tandem repeats with high sequence similarities to each other (up to 73%) and does not belong to any known lectins family. According to circular dichroism results CGL is a β/α-protein with the predominance of β-structure. CGL was predicted to adopt a ß-trefoil fold. The lectin exhibits antibacterial activity and might be involved in the recognition and clearance of bacterial pathogens in the shellfish.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amino acid sequence; Antibacterial activity; Crenomytilus grayanus; GalNAc/Gal-specific lectin; ß-trefoil fold

Mesh：

Substances：

Year:  2013        PMID： 23886951     DOI： 10.1016/j.fsi.2013.07.011

Source DB:  PubMed          Journal:  Fish Shellfish Immunol        ISSN： 1050-4648            Impact factor:   4.581


  15 in total

1.  MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.

Authors:  Imtiaj Hasan; Shigeki Sugawara; Yuki Fujii; Yasuhiro Koide; Daiki Terada; Naoya Iimura; Toshiyuki Fujiwara; Keisuke G Takahashi; Nobuhiko Kojima; Sultana Rajia; Sarkar M A Kawsar; Robert A Kanaly; Hideho Uchiyama; Masahiro Hosono; Yukiko Ogawa; Hideaki Fujita; Jiharu Hamako; Taei Matsui; Yasuhiro Ozeki
Journal:  Mar Drugs       Date:  2015-12-14       Impact factor: 5.118

2.  Crystal structure of MytiLec, a galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types.

Authors:  Daiki Terada; Fumihiro Kawai; Hiroki Noguchi; Satoru Unzai; Imtiaj Hasan; Yuki Fujii; Sam-Yong Park; Yasuhiro Ozeki; Jeremy R H Tame
Journal:  Sci Rep       Date:  2016-06-20       Impact factor: 4.379

3.  A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice.

Authors:  Oleg V Chernikov; Wei-Ting Wong; Lan-Hui Li; Irina V Chikalovets; Valentina I Molchanova; Shih-Hsiung Wu; Jiahn-Haur Liao; Kuo-Feng Hua
Journal:  Sci Rep       Date:  2017-07-24       Impact factor: 4.379

Review 4.  Antiviral lectins: Selective inhibitors of viral entry.

Authors:  Carter A Mitchell; Koreen Ramessar; Barry R O'Keefe
Journal:  Antiviral Res       Date:  2017-03-18       Impact factor: 5.970

5.  A lectin of a non-invasive apple snail as an egg defense against predation alters the rat gut morphophysiology.

Authors:  Santiago Ituarte; Tabata Romina Brola; Patricia Elena Fernández; Huawei Mu; Jian-Wen Qiu; Horacio Heras; Marcos Sebastián Dreon
Journal:  PLoS One       Date:  2018-06-01       Impact factor: 3.240

6.  A GM1b/asialo-GM1 oligosaccharide-binding R-type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases.

Authors:  Yuki Fujii; Marco Gerdol; Sarkar M A Kawsar; Imtiaj Hasan; Francesca Spazzali; Tatsusada Yoshida; Yukiko Ogawa; Sultana Rajia; Kenichi Kamata; Yasuhiro Koide; Shigeki Sugawara; Masahiro Hosono; Jeremy R H Tame; Hideaki Fujita; Alberto Pallavicini; Yasuhiro Ozeki
Journal:  FEBS J       Date:  2019-12-24       Impact factor: 5.542

7.  MytiLec-1 Shows Glycan-Dependent Toxicity against Brine Shrimp Artemia and Induces Apoptotic Death of Ehrlich Ascites Carcinoma Cells In Vivo.

Authors:  Imtiaj Hasan; A K M Asaduzzaman; Rubaiya Rafique Swarna; Yuki Fujii; Yasuhiro Ozeki; Md Belal Uddin; Syed Rashel Kabir
Journal:  Mar Drugs       Date:  2019-08-28       Impact factor: 5.118

Review 8.  Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential.

Authors:  Johan Gardères; Marie-Lise Bourguet-Kondracki; Bojan Hamer; Renato Batel; Heinz C Schröder; Werner E G Müller
Journal:  Mar Drugs       Date:  2015-08-07       Impact factor: 5.118

9.  cDNA and Gene Structure of MytiLec-1, A Bacteriostatic R-Type Lectin from the Mediterranean Mussel (Mytilus galloprovincialis).

Authors:  Imtiaj Hasan; Marco Gerdol; Yuki Fujii; Sultana Rajia; Yasuhiro Koide; Daiki Yamamoto; Sarkar M A Kawsar; Yasuhiro Ozeki
Journal:  Mar Drugs       Date:  2016-05-11       Impact factor: 5.118

10.  Computational design of a symmetrical β-trefoil lectin with cancer cell binding activity.

Authors:  Daiki Terada; Arnout R D Voet; Hiroki Noguchi; Kenichi Kamata; Mio Ohki; Christine Addy; Yuki Fujii; Daiki Yamamoto; Yasuhiro Ozeki; Jeremy R H Tame; Kam Y J Zhang
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
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