Guangfeng Gao1, Biyan Gong, Wen Shen. 1. Department of Radiology, The First Central Hospital of Tianjin, Fu'kang Road No. 24, Tianjin 300192, China.
Abstract
BACKGROUND: We performed a meta-analysis to compare the diagnostic performance of integrated (18)FDG PET-CT with that of (18)FDG PET alone and CT alone for the overall assessment of tumor distant metastases. METHODS: We performed a meta-analysis of 11 available articles (1107 patients). We calculated sensitivities, specificities, positive likelihood ratios, and negative likelihood ratios for integrated PET-CT, PET alone, and CT alone, respectively. We also constructed summary receiver operating characteristic curves for integrated PET-CT, PET alone, and CT alone, respectively. RESULTS: Across 10 comparative studies (1058 patients), integrated PET-CT has higher sensitivity (0.95 vs 0.85) and similar specificity (0.96 vs 0.95) with PET alone. Across 7 comparative studies (745 patients), integrated PET-CT has higher sensitivity (0.97 vs 0.80) and similar specificity (0.97 vs 0.94) with CT alone. CONCLUSION: Integrated PET-CT is the most sensitive and accurate modality for tumor distant metastasis staging. Integrating PET with CT may tend to improve the sensitivity than PET alone and CT alone.
BACKGROUND: We performed a meta-analysis to compare the diagnostic performance of integrated (18)FDG PET-CT with that of (18)FDG PET alone and CT alone for the overall assessment of tumor distant metastases. METHODS: We performed a meta-analysis of 11 available articles (1107 patients). We calculated sensitivities, specificities, positive likelihood ratios, and negative likelihood ratios for integrated PET-CT, PET alone, and CT alone, respectively. We also constructed summary receiver operating characteristic curves for integrated PET-CT, PET alone, and CT alone, respectively. RESULTS: Across 10 comparative studies (1058 patients), integrated PET-CT has higher sensitivity (0.95 vs 0.85) and similar specificity (0.96 vs 0.95) with PET alone. Across 7 comparative studies (745 patients), integrated PET-CT has higher sensitivity (0.97 vs 0.80) and similar specificity (0.97 vs 0.94) with CT alone. CONCLUSION: Integrated PET-CT is the most sensitive and accurate modality for tumor distant metastasis staging. Integrating PET with CT may tend to improve the sensitivity than PET alone and CT alone.
Authors: Jacqueline Dinnes; Lavinia Ferrante di Ruffano; Yemisi Takwoingi; Seau Tak Cheung; Paul Nathan; Rubeta N Matin; Naomi Chuchu; Sue Ann Chan; Alana Durack; Susan E Bayliss; Abha Gulati; Lopa Patel; Clare Davenport; Kathie Godfrey; Manil Subesinghe; Zoe Traill; Jonathan J Deeks; Hywel C Williams Journal: Cochrane Database Syst Rev Date: 2019-07-01