| Literature DB >> 238864 |
J A Dominic, A K Sinha, J D Barchas.
Abstract
In mice, chlordiazepoxide, diazepam and flurazepam reduced 5-HT synthesis and metabolism in the teldiencephalon following an i.v. injection of 3H-tryptophan. Only diazepam produced a significant effect in the brainstem. The steady state level of brain 5-HT or of tryptophan was not altered by any of the drugs. Chlordiazepoxide and diazepam, but not flurazepam, decreased the rate of norepinephrine loss from the brain following inhibition of synthesis with alpha-methyltyrosine.Entities:
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Year: 1975 PMID： 238864 DOI： 10.1016/0014-2999(75)90332-5
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432