[Paracrine activity of multipotent mesenchymal stromal cells and its modulation at hypoxia].

Multipotent mesenchymal stromal (stem) cells (MMSCs) play an important role in the structural and functional balance in tissue remodeling and reparation. M MSCs synthesize broad spectrum of soluble mediators that includes molecules with immunomodulatory, anti-apoptotic, pro-angiogenic, hemoattrative, supportive and other effects. Microenvironmental factors, such as cell-tocell contacts, connective tissue matrix and the partial oxygen pressure can significantly affect the profile of MMSC-produced papracrine mediators, and therefore, change their biological activity. The present review analyses the recent data concerning MMSC paracrine profile and its modulation at hypoxia that is specific to its physiological mileu.