Literature DB >> 23885159

Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan.

Darryl Lim1, Ser Yee Lee, Kiat Hon Lim, Chung Yip Chan.   

Abstract

Positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) is an imaging modality which reflects cellular glucose metabolism. Most malignant cells accumulate and trap ¹⁸F-FDG, allowing the visualisation of increased uptake. It is hence widely used to differentiate malignant from benign lesions. "False positive" findings of hepatic lesions have been described in certain instances such as hepatic abscesses, but are rare in cases involving hepatocellular adenomas. To our knowledge, there have been only 7 reports in the English literature documenting PET-avid hepatocellular adenomas; 6 of the 7 reports were published in the last 3 years with the first report by Patel et al. We report the case of a 44-year-old Chinese female patient with a history of cervical adenocarcinoma, referred for a hepatic lesion noted on a surveillance computed tomography (CT) scan. A subsequent CT-PET performed showed a hypermetabolic lesion (standardized uptake value 7.9) in segment IVb of the liver. After discussion at a multi-disciplinary hepato-pancreato-biliary conference, the consensus was that of a metastatic lesion from her previous cervical adenocarcinoma, and a resection of the hepatic lesion was performed. Histology revealed features consistent with a hepatocyte nuclear factor-1 α inactivated steatotic hepatocellular adenoma.

Entities:  

Keywords:  18F-fluorodeoxyglucose; Hepatic adenoma; Hepatocellular adenoma; Hepatocyte nuclear factor-1 α; Positron emission tomography

Mesh:

Substances:

Year:  2013        PMID: 23885159      PMCID: PMC3718916          DOI: 10.3748/wjg.v19.i27.4432

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN: 1007-9327            Impact factor:   5.742


  33 in total

Review 1.  Approach to a liver mass.

Authors:  K R Reddy; E R Schiff
Journal:  Semin Liver Dis       Date:  1993-11       Impact factor: 6.115

2.  Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium.

Authors:  Matthanja Bieze; Jacomina W van den Esschert; C Yung Nio; Joanne Verheij; Johannes B Reitsma; Valeska Terpstra; Thomas M van Gulik; Saffire S K S Phoa
Journal:  AJR Am J Roentgenol       Date:  2012-07       Impact factor: 3.959

3.  Role of contrast-enhanced sonography in differentiation of subtypes of hepatocellular adenoma: correlation with MRI findings.

Authors:  Hervé Laumonier; Hélène Cailliez; Charles Balabaud; Laurent Possenti; Jessica Zucman-Rossi; Paulette Bioulac-Sage; Hervé Trillaud
Journal:  AJR Am J Roentgenol       Date:  2012-08       Impact factor: 3.959

4.  Clinical applications of positron emission tomography in hepatic tumors.

Authors:  Susumu Shiomi; Joji Kawabe
Journal:  Hepatol Res       Date:  2011-07       Impact factor: 4.288

5.  Positron emission tomography scanning in the evaluation of hepatocellular carcinoma.

Authors:  M A Khan; C S Combs; E M Brunt; V J Lowe; M K Wolverson; H Solomon; B T Collins; A M Di Bisceglie
Journal:  J Hepatol       Date:  2000-05       Impact factor: 25.083

Review 6.  Genetics and imaging of hepatocellular adenomas: 2011 update.

Authors:  Venkata S Katabathina; Christine O Menias; Alampady K P Shanbhogue; Jaishree Jagirdar; Raj Mohan Paspulati; Srinivasa R Prasad
Journal:  Radiographics       Date:  2011-10       Impact factor: 5.333

7.  The role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma.

Authors:  L James Wudel; Dominique Delbeke; David Morris; Michael Rice; Mary Kay Washington; Yu Shyr; C Wright Pinson; William C Chapman
Journal:  Am Surg       Date:  2003-02       Impact factor: 0.688

8.  Whole-body FDG-PET/CT on rheumatoid arthritis of large joints.

Authors:  Kazuo Kubota; Kimiteru Ito; Miyako Morooka; Takuya Mitsumoto; Kyoko Kurihara; Hiroyuki Yamashita; Yuko Takahashi; Akio Mimori
Journal:  Ann Nucl Med       Date:  2009-10-16       Impact factor: 2.668

9.  Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience.

Authors:  Paulette Bioulac-Sage; Hervé Laumonier; Gabrielle Couchy; Brigitte Le Bail; Antonio Sa Cunha; Anne Rullier; Christophe Laurent; Jean-Frédéric Blanc; Gaelle Cubel; Hervé Trillaud; Jessica Zucman-Rossi; Charles Balabaud; Jean Saric
Journal:  Hepatology       Date:  2009-08       Impact factor: 17.425

10.  Uptake of (18) FDG by a Hepatic Adenoma on Positron Emission Tomography.

Authors:  J A Stephenson; T Kapasi; O Al-Taan; A R Dennison
Journal:  Case Reports Hepatol       Date:  2011-12-22
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  5 in total

1.  Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high (18)F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation.

Authors:  Kumi Ozaki; Kenichi Harada; Noboru Terayama; Osamu Matsui; Satoshi Saitoh; Yoshito Tomimaru; Takeshi Fujii; Toshifumi Gabata
Journal:  Br J Radiol       Date:  2016-05-20       Impact factor: 3.039

2.  PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.

Authors:  Ser Yee Lee; T Peter Kingham; Maria D LaGratta; Jose Jessurun; Daniel Cherqui; William R Jarnagin; Michael D Kluger
Journal:  HPB (Oxford)       Date:  2015-12-11       Impact factor: 3.647

3.  Tumor-Like Liver Abscess Mimicking Malignancy With Lung Metastases in a Patient With Acute Renal Failure: A Case Report.

Authors:  Chih Hsin Wang; Cheuk-Kay Sun; Jiunn-Song Jiang; Ming Hsien Tsai
Journal:  Medicine (Baltimore)       Date:  2016-03       Impact factor: 1.889

4.  18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma: A case report.

Authors:  Willy Liu; Jean Delwaide; Noella Bletard; Philippe Delvenne; Paul Meunier; Roland Hustinx; Olivier Detry
Journal:  World J Hepatol       Date:  2017-04-18

5.  False-positive 18F fluorodeoxyglucose positron emission tomography-avid benign hepatic tumor: Previously unreported in a male patient.

Authors:  Binit Sureka; Archana Rastogi; Amar Mukund; Shiv Kumar Sarin
Journal:  Indian J Radiol Imaging       Date:  2018 Apr-Jun
  5 in total

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