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Literature DB >> 23884378

Endothelin 1 in cancer: biological implications and therapeutic opportunities.

Laura Rosanò¹, Francesca Spinella, Anna Bagnato.

Abstract

Activation of autocrine and paracrine signalling by endothelin 1 (ET1) binding to its receptors elicits pleiotropic effects on tumour cells and on the host microenvironment. This activation modulates cell proliferation, apoptosis, migration, epithelial-to-mesenchymal transition, chemoresistance and neovascularization, thus providing a strong rationale for targeting ET1 receptors in cancer. In this Review, we discuss the advances in our understanding of the diverse biological roles of ET1 in cancer and describe the latest preclinical and clinical progress that has been made using small-molecule antagonists of ET1 receptors that inhibit ET1-driven signalling.

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23884378 DOI： 10.1038/nrc3546

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

149 in total

1. Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan.

Authors: Li-Sung Hsu; Hsin-Chen Lee; Gar-Yang Chau; Pen-Hui Yin; Chin-Wen Chi; Wing Yiu Lui
Journal: Oncol Rep Date: 2006-02 Impact factor: 3.906

2. Molecular classification of cutaneous malignant melanoma by gene expression profiling.

Authors: M Bittner; P Meltzer; Y Chen; Y Jiang; E Seftor; M Hendrix; M Radmacher; R Simon; Z Yakhini; A Ben-Dor; N Sampas; E Dougherty; E Wang; F Marincola; C Gooden; J Lueders; A Glatfelter; P Pollock; J Carpten; E Gillanders; D Leja; K Dietrich; C Beaudry; M Berens; D Alberts; V Sondak
Journal: Nature Date: 2000-08-03 Impact factor: 49.962

3. Role of endothelin-1 in neovascularization of ovarian carcinoma.

Authors: D Salani; V Di Castro; M R Nicotra; L Rosanò; R Tecce; A Venuti; P G Natali; A Bagnato
Journal: Am J Pathol Date: 2000-11 Impact factor: 4.307

4. Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone.

Authors: Joel B Nelson; Karim Fizazi; Kurt Miller; Celestia Higano; Judd W Moul; Hideyuki Akaza; Thomas Morris; Stuart McIntosh; Kristine Pemberton; Martin Gleave
Journal: Cancer Date: 2012-07-11 Impact factor: 6.860

5. Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.

Authors: A Bagnato; D Salani; V Di Castro; J R Wu-Wong; R Tecce; M R Nicotra; A Venuti; P G Natali
Journal: Cancer Res Date: 1999-02-01 Impact factor: 12.701

6. Distinct patterns of endothelin axis expression in primary prostate cancer.

Authors: Geeta Godara; Stefana Pecher; Drazen M Jukic; Jason M D'Antonio; Ardavan Akhavan; Joel B Nelson; Beth R Pflug
Journal: Urology Date: 2007-07 Impact factor: 2.649

7. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors.

Authors: H Daub; F U Weiss; C Wallasch; A Ullrich
Journal: Nature Date: 1996-02-08 Impact factor: 49.962

8. Detection of previously unidentified metastatic disease as a leading cause of screening failure in a phase III trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer.

Authors: Evan Y Yu; Kurt Miller; Joel Nelson; Martin Gleave; Karim Fizazi; Judd W Moul; Faith E Nathan; Celestia S Higano
Journal: J Urol Date: 2012-05-12 Impact factor: 7.450

9. Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival.

Authors: S L Smith; B E Damato; A G M Scholes; J Nunn; J K Field; J Heighway
Journal: Br J Cancer Date: 2002-11-18 Impact factor: 7.640

10. Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization.

Authors: Katrin Lange; Martial Kammerer; Monika E Hegi; Stefan Grotegut; Antje Dittmann; Wentao Huang; Erika Fluri; George W Yip; Martin Götte; Christian Ruiz; Gertraud Orend
Journal: Cancer Res Date: 2007-07-01 Impact factor: 12.701

112 in total

1. Rendomab B4, a monoclonal antibody that discriminates the human endothelin B receptor of melanoma cells and inhibits their migration.

Authors: Aurélie Borrull; Bertrand Allard; Anne Wijkhuisen; Amaury Herbet; Patricia Lamourette; Wided Birouk; Denis Leiber; Zahra Tanfin; Frédéric Ducancel; Didier Boquet; Jean-Yves Couraud; Philippe Robin
Journal: MAbs Date: 2016-07-08 Impact factor: 5.857

2. Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells.

Authors: Terry W Moody; Irene Ramos-Alvarez; Paula Moreno; Samuel A Mantey; Lisa Ridnour; David Wink; Robert T Jensen
Journal: Peptides Date: 2017-01-31 Impact factor: 3.750

3. Endothelin-1 differentially directs lineage specification of adipose- and bone marrow-derived mesenchymal stem cells.

Authors: Ming-Song Lee; Jesse Wang; Huihua Yuan; Hongli Jiao; Tsung-Lin Tsai; Matthew W Squire; Wan-Ju Li
Journal: FASEB J Date: 2018-08-10 Impact factor: 5.191

Review 4. Inhibition of ENaC by endothelin-1.

Authors: Andrey Sorokin; Alexander Staruschenko
Journal: Vitam Horm Date: 2015-03-06 Impact factor: 3.421

Review 5. Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.

Authors: Nijiro Nohata; Yusuke Goto; J Silvio Gutkind
Journal: J Hum Genet Date: 2016-10-13 Impact factor: 3.172

6. X-ray structures of endothelin ET_B receptor bound to clinical antagonist bosentan and its analog.

Authors: Wataru Shihoya; Tomohiro Nishizawa; Keitaro Yamashita; Asuka Inoue; Kunio Hirata; Francois Marie Ngako Kadji; Akiko Okuta; Kazutoshi Tani; Junken Aoki; Yoshinori Fujiyoshi; Tomoko Doi; Osamu Nureki
Journal: Nat Struct Mol Biol Date: 2017-08-14 Impact factor: 15.369

7. Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice.

Authors: Malgorzata Kasztan; Brandon M Fox; Joshua S Speed; Carmen De Miguel; Eman Y Gohar; Tim M Townes; Abdullah Kutlar; Jennifer S Pollock; David M Pollock
Journal: J Am Soc Nephrol Date: 2017-03-27 Impact factor: 10.121

8. Activation mechanism of endothelin ET_B receptor by endothelin-1.

Authors: Wataru Shihoya; Tomohiro Nishizawa; Akiko Okuta; Kazutoshi Tani; Naoshi Dohmae; Yoshinori Fujiyoshi; Osamu Nureki; Tomoko Doi
Journal: Nature Date: 2016-09-05 Impact factor: 49.962

Review 9. Endothelin-1 receptor drives invadopodia: Exploiting how β-arrestin-1 guides the way.

Authors: Anna Bagnato; Laura Rosanò
Journal: Small GTPases Date: 2016-10-03

10. Endothelin-1-Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma.

Authors: Inés Pulido; Stephen Ollosi; Salvador Aparisi; Jeffrey H Becker; Alicia Aliena-Valero; Marta Benet; María L Rodríguez; Adrián López; Eva Tamayo-Torres; Lourdes Chuliá-Peris; Juan Carlos García-Cañaveras; Margaret Soucheray; Annika V Dalheim; Juan B Salom; Wei Qiu; Simon Kaja; Javier Alcácer Fernández-Coronado; Sandra Alandes; Javier Alcácer; Fátima Al-Shahrour; Jeffrey A Borgia; Oscar Juan; Michael I Nishimura; Agustín Lahoz; Julián Carretero; Takeshi Shimamura
Journal: Cancer Res Date: 2020-08-03 Impact factor: 12.701