| Literature DB >> 23883415 |
Thomas Johnson1, Mark Lautens.
Abstract
Trifluoromethylacetaldimines, generated in situ from the corresponding N,O-acetals, undergo 1,2-addition of arylboroxines under palladium(II) catalysis to generate a variety of α-(trifluoromethyl)arylmethylamines with good to high enantioselectivity (up to 97% ee). The pyridine-oxazolidine (PyOX) class of ligands was found to be particularly suitable for this transformation, which proceeds without exclusion of ambient air and moisture.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23883415 DOI： 10.1021/ol401862g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005