Literature DB >> 2388328

Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose.

S A Berger1, H Yavetz, G Paz, A Gorea, Z Homonnai.   

Abstract

A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.

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Year:  1990        PMID: 2388328     DOI: 10.1016/s0022-5347(17)39554-x

Source DB:  PubMed          Journal:  J Urol        ISSN: 0022-5347            Impact factor:   7.450


  7 in total

Review 1.  Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use.

Authors:  P A Todd; D Faulds
Journal:  Drugs       Date:  1991-11       Impact factor: 9.546

2.  The effects of sildenafil on human sperm function in healthy volunteers.

Authors:  Ken Purvis; Gary J Muirhead; Jane A Harness
Journal:  Br J Clin Pharmacol       Date:  2002       Impact factor: 4.335

3.  A new method to estimate quantitatively seminal vesicle and prostate gland contributions to ejaculate.

Authors:  Themba T Ndovi; Teresa Parsons; Leena Choi; Brian Caffo; Charles Rohde; Craig W Hendrix
Journal:  Br J Clin Pharmacol       Date:  2006-10-31       Impact factor: 4.335

4.  Penetration of ofloxacin into prostatic fluid, ejaculate and seminal fluid.

Authors:  K G Naber; M Kinzig; F Sörgel; D Weigel
Journal:  Infection       Date:  1993 Mar-Apr       Impact factor: 3.553

Review 5.  Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections.

Authors:  S V Onrust; H M Lamb; J A Balfour
Journal:  Drugs       Date:  1998-11       Impact factor: 9.546

Review 6.  Drugs in semen.

Authors:  S Pichini; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1994-05       Impact factor: 6.447

Review 7.  Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability.

Authors:  R Davis; A Markham; J A Balfour
Journal:  Drugs       Date:  1996-06       Impact factor: 9.546

  7 in total

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