PURPOSE: We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT). METHODS: Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT. RESULTS: In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm). CONCLUSIONS: Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.
PURPOSE: We investigated effects of smoking and other risk factors on the development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thickness (CCT). METHODS: Eyes from Caucasian probands, affected and unaffected family members, and unrelated controls matched for age from the FECD Genetics Multi-Center Study (n = 2044 subjects) were examined. Univariate and multivariate models, adjusted for family correlations, were used to determine the effect of smoking, sex, diabetes, and age on FECD case/control status and CCT. RESULTS: In a multivariate model, sex and smoking were associated significantly with advanced FECD (grades 4-6) development (P = 0.016 and P = 0.047, respectively). Female sex increased odds by 34%. Smoking increased odds by 30%. In a multivariate model, diabetes was associated with an increase of 9.1 μm in average CCT (P = 0.021). Female sex was associated significantly with a decrease in average CCT by 6.9 μm (P = 0.015). Smoking had no significant effect on CCT in any model. As shown previously, advanced FECD was associated with large increases in CCT (31.4-94.2 μm). CONCLUSIONS: Smoking was associated with an increased risk of advanced FECD and self-reported diabetes was associated with increased CCT. Further study of the impact of smoking and diabetes on FECD development and changes in corneal thickness is warranted.
Authors: J H Lass; R V Spurney; R M Dutt; H Andersson; H Kochar; H M Rodman; R C Stern; C F Doershuk Journal: Am J Ophthalmol Date: 1985-12-15 Impact factor: 5.258
Authors: Kishore Reddy Katikireddy; Tomas L White; Taiga Miyajima; Shivakumar Vasanth; Duna Raoof; Yuming Chen; Marianne O Price; Francis W Price; Ula V Jurkunas Journal: Free Radic Biol Med Date: 2017-12-30 Impact factor: 7.376
Authors: Alan Sugar; Robin L Gal; Craig Kollman; Dan Raghinaru; Mariya Dontchev; Christopher R Croasdale; Robert S Feder; Edward J Holland; Jonathan H Lass; Jonathan I Macy; Mark J Mannis; Patricia W Smith; Sarkis H Soukiasian; Roy W Beck Journal: JAMA Ophthalmol Date: 2015-03 Impact factor: 7.389
Authors: Yi-Ju Li; Mollie A Minear; Xuejun Qin; Jacqueline Rimmler; Michael A Hauser; R Rand Allingham; Robert P Igo; Jonathan H Lass; Sudha K Iyengar; Gordon K Klintworth; Natalie A Afshari; Simon G Gregory Journal: Invest Ophthalmol Vis Sci Date: 2014-06-10 Impact factor: 4.799
Authors: Stephan Ong Tone; Viridiana Kocaba; Myriam Böhm; Adam Wylegala; Tomas L White; Ula V Jurkunas Journal: Prog Retin Eye Res Date: 2020-05-08 Impact factor: 21.198