Literature DB >> 23881906

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.

Bin Shen1, Jongho Jeon, Mikael Palner, Deju Ye, Adam Shuhendler, Frederick T Chin, Jianghong Rao.   

Abstract

Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  apoptosis; caspase-3; cyclization; drug design; positron emission tomography

Mesh：

Substances：

Year:  2013        PMID： 23881906      PMCID： PMC4077287          DOI： 10.1002/anie.201303422

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  24 in total

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Authors:  M Iyer; J R Barrio; M Namavari; E Bauer; N Satyamurthy; K Nguyen; T Toyokuni; M E Phelps; H R Herschman; S S Gambhir
Journal:  J Nucl Med       Date:  2001-01       Impact factor: 10.057

Review 2.  Molecular imaging of cancer with positron emission tomography.

Authors:  Sanjiv Sam Gambhir
Journal:  Nat Rev Cancer       Date:  2002-09       Impact factor: 60.716

3.  Apoptosis at a distance: remote activation of caspase-3 occurs early after myocardial infarction.

Authors:  Kerstin Schwarz; Gregor Simonis; Xinjian Yu; Stephan Wiedemann; Ruth H Strasser
Journal:  Mol Cell Biochem       Date:  2006-01       Impact factor: 3.396

4.  Early caspase-3 activation independent of apoptosis is required for cellular function.

Authors:  Juan A Rosado; Jose J Lopez; Emilio Gomez-Arteta; Pedro C Redondo; Gines M Salido; Jose A Pariente
Journal:  J Cell Physiol       Date:  2006-10       Impact factor: 6.384

5.  Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo(a)pyrene.

Authors:  W Lei; R Yu; S Mandlekar; A N Kong
Journal:  Cancer Res       Date:  1998-05-15       Impact factor: 12.701

6.  The nonpeptidyl caspase binding radioligand (S)-1-(4-(2-[18F]Fluoroethoxy)-benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin ([18F]CbR) as potential positron emission tomography-compatible apoptosis imaging agent.

Authors:  A Faust; S Wagner; M P Law; S Hermann; U Schnöckel; P Keul; O Schober; M Schäfers; B Levkau; K Kopka
Journal:  Q J Nucl Med Mol Imaging       Date:  2007-03       Impact factor: 2.346

7.  Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.

Authors:  Juri Gelovani Tjuvajev; Mikhail Doubrovin; Timothy Akhurst; Shangde Cai; Julius Balatoni; Mian M Alauddin; Ronald Finn; William Bornmann; Howard Thaler; Peter S Conti; Ronald G Blasberg
Journal:  J Nucl Med       Date:  2002-08       Impact factor: 10.057

8.  Positron emission tomography.

Authors:  E J Hoffman; M E Phelps
Journal:  Med Instrum       Date:  1979 May-Jun

9.  Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model.

Authors:  Edward M Barnett; Xu Zhang; Dustin Maxwell; Qing Chang; David Piwnica-Worms
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-20       Impact factor: 11.205

10.  [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98.

Authors:  Dong Zhou; Wenhua Chu; Delphine L Chen; Qi Wang; David E Reichert; Justin Rothfuss; Andre D'Avignon; Michael J Welch; Robert H Mach
Journal:  Org Biomol Chem       Date:  2009-02-16       Impact factor: 3.876
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  26 in total

Review 1.  Molecular imaging-its current role in cancer.

Authors:  S McDermott; A Kilcoyne
Journal:  QJM       Date:  2015-08-07

2.  A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment.

Authors:  Timothy H Witney; Aileen Hoehne; Robert E Reeves; Ohad Ilovich; Mohammad Namavari; Bin Shen; Frederick T Chin; Jianghong Rao; Sanjiv S Gambhir
Journal:  Clin Cancer Res       Date:  2015-05-13       Impact factor: 12.531

Review 3.  Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.

Authors:  Colman Moore; Fang Chen; Junxin Wang; Jesse V Jokerst
Journal:  Adv Drug Deliv Rev       Date:  2019-07-08       Impact factor: 15.470

4.  [18F]-C-SNAT4: an improved caspase-3-sensitive nanoaggregation PET tracer for imaging of tumor responses to chemo- and immunotherapies.

Authors:  Min Chen; Zixin Chen; Jessa B Castillo; Liyang Cui; Kaixiang Zhou; Bin Shen; Jinghang Xie; Frederick T Chin; Jianghong Rao
Journal:  Eur J Nucl Med Mol Imaging       Date:  2021-03-13       Impact factor: 9.236

5.  Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer.

Authors:  Jeffrey Collins; Christopher M Waldmann; Christopher Drake; Roger Slavik; Noel S Ha; Maxim Sergeev; Mark Lazari; Bin Shen; Frederick T Chin; Melissa Moore; Saman Sadeghi; Michael E Phelps; Jennifer M Murphy; R Michael van Dam
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-10       Impact factor: 11.205

6.  Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis.

Authors:  Zhe Wang; Fu Wang; Naoki Hida; Dale O Kiesewetter; Jie Tian; Gang Niu; Xiaoyuan Chen
Journal:  Nat Protoc       Date:  2015-04-30       Impact factor: 13.491

7.  Towards clinically translatable in vivo nanodiagnostics.

Authors:  Seung-Min Park; Amin Aalipour; Ophir Vermesh; Jung Ho Yu; Sanjiv S Gambhir
Journal:  Nat Rev Mater       Date:  2017-05-03       Impact factor: 66.308

8.  Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis.

Authors:  Deju Ye; Adam J Shuhendler; Prachi Pandit; Kimberly D Brewer; Sui Seng Tee; Lina Cui; Grigory Tikhomirov; Brian Rutt; Jianghong Rao
Journal:  Chem Sci       Date:  2014-10-01       Impact factor: 9.825

9.  Exploring the Condensation Reaction between Aromatic Nitriles and Amino Thiols To Optimize In Situ Nanoparticle Formation for the Imaging of Proteases and Glycosidases in Cells.

Authors:  Zixin Chen; Min Chen; Yunfeng Cheng; Toshiyuki Kowada; Jinghang Xie; Xianchuang Zheng; Jianghong Rao
Journal:  Angew Chem Int Ed Engl       Date:  2020-01-21       Impact factor: 15.336

10.  Reduction Triggered In Situ Polymerization in Living Mice.

Authors:  Lina Cui; Sandro Vivona; Bryan Ronain Smith; Sri-Rajasekhar Kothapalli; Jun Liu; Xiaowei Ma; Zixin Chen; Madelynn Taylor; Paul H Kierstead; Jean M J Fréchet; Sanjiv S Gambhir; Jianghong Rao
Journal:  J Am Chem Soc       Date:  2020-08-31       Impact factor: 15.419
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