Literature DB >> 23881640

Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro.

Yan Pan1, Kai Hung Tiong, Badrul Amini Abd-Rashid, Zakiah Ismail, Rusli Ismail, Joon Wah Mak, Chin Eng Ong.   

Abstract

Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. Our results indicated that eurycomanone did not potently inhibit any of the CYP isoforms investigated, with IC50 values greater than 250 μg/ml. Hence there appears to be little likelihood of drug-herb interaction between eurycomanone or herbal products with high content of this compound and CYP drug substrates via CYP inhibition.

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Year:  2013        PMID： 23881640     DOI： 10.1007/s11418-013-0794-8

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  23 in total

1.  In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.

Authors:  Yan Pan; Badrul Amini Abd-Rashid; Zakiah Ismail; Rusli Ismail; Joon Wah Mak; Peter C K Pook; Hui Meng Er; Chin Eng Ong
Journal:  J Ethnopharmacol       Date:  2010-05-08       Impact factor: 4.360

Review 2.  Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance.

Authors:  Rajeev Bhat; A A Karim
Journal:  Fitoterapia       Date:  2010-04-29       Impact factor: 2.882

3.  Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract.

Authors:  S A B Salman; S Amrah; M S A Wahab; Z Ismail; R Ismail; K H Yuen; S H Gan
Journal:  J Clin Pharm Ther       Date:  2010-12       Impact factor: 2.512

4.  Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity.

Authors:  Bin-Seng Low; Chin-Hoe Teh; Kah-Hay Yuen; Kit-Lam Chan
Journal:  Nat Prod Commun       Date:  2011-03       Impact factor: 0.986

5.  Semisynthetic 15-O-acyl- and 1,15-di-O-acyleurycomanones from Eurycoma longifolia as potential antimalarials.

Authors:  Kit-Lam Chan; Chee-Yan Choo; Noor Rain Abdullah
Journal:  Planta Med       Date:  2005-10       Impact factor: 3.352

Review 6.  Molecular evolution of P450 superfamily and P450-containing monooxygenase systems.

Authors:  K N Degtyarenko; A I Archakov
Journal:  FEBS Lett       Date:  1993-10-11       Impact factor: 4.124

7.  Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28.

Authors:  Pooi-Fong Wong; Wei-Fun Cheong; Meng-Hooi Shu; Chin-Hoe Teh; Kit-Lam Chan; Sazaly AbuBakar
Journal:  Phytomedicine       Date:  2011-09-07       Impact factor: 5.340

8.  Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes.

Authors:  Anima Ghosal; Neil Hapangama; Yuan Yuan; Xiaowen Lu; Debra Horne; James E Patrick; Shmuel Zbaida
Journal:  Biopharm Drug Dispos       Date:  2003-12       Impact factor: 1.627

9.  Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey.

Authors:  D M Eisenberg; R B Davis; S L Ettner; S Appel; S Wilkey; M Van Rompay; R C Kessler
Journal:  JAMA       Date:  1998-11-11       Impact factor: 56.272

10.  Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53.

Authors:  Yusmazura Zakaria; Asmah Rahmat; Azimahtol Hawariah Lope Pihie; Noor Rain Abdullah; Peter J Houghton
Journal:  Cancer Cell Int       Date:  2009-06-10       Impact factor: 5.722
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  6 in total

1.  In Vitro and In Vivo Effect of Xylopic Acid on Cytochrome P450 Enzymes.

Authors:  Mary A Agbenyeku; Regina Appiah-Opong; Ernest Obese; Robert P Biney; Emmanuel A Adakudugu; Arnold D Forkuo; Silas A Osei; Mustapha K Abeka; Elvis O Ameyaw
Journal:  Adv Pharmacol Pharm Sci       Date:  2022-01-21

2.  In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism.

Authors:  Young Min Han; In Sook Kim; Shaheed Ur Rehman; Kevin Choe; Hye Hyun Yoo
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-09       Impact factor: 2.629

3.  Effects of Curcuma xanthorrhiza Extracts and Their Constituents on Phase II Drug-metabolizing Enzymes Activity.

Authors:  Nurul Afifah Mohd Salleh; Sabariah Ismail; Mohd Rohaimi Ab Halim
Journal:  Pharmacognosy Res       Date:  2016 Oct-Dec

4.  Effect of citral on mouse hepatic cytochrome P450 enzymes.

Authors:  Huaqiao Tang; Nana Long; Min Dai; Lin Lin; Jianlong Li; Fenghui Sun; Lijuan Guo
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

5.  Bioavailability of Eurycomanone in Its Pure Form and in a Standardised Eurycoma longifolia Water Extract.

Authors:  Norzahirah Ahmad; Dodheri Syed Samiulla; Bee Ping Teh; Murizal Zainol; Nor Azlina Zolkifli; Amirrudin Muhammad; Emylyn Matom; Azlina Zulkapli; Noor Rain Abdullah; Zakiah Ismail; Ami Fazlin Syed Mohamed
Journal:  Pharmaceutics       Date:  2018-07-11       Impact factor: 6.321

6.  In vitro inhibitory effect of obtusofolin on the activity of CYP3A4, 2C9, and 2E1.

Authors:  Na Liu; Ping Chen; Xiaojun Du; Junxia Sun; Shasha Han
Journal:  BMC Complement Med Ther       Date:  2021-09-01
  6 in total

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