| Literature DB >> 23881160 |
Josef Fulka1, Alena Langerova, Pasqualino Loi, Grazyna Ptak, David Albertini, Helena Fulka.
Abstract
Achieving successful somatic cell nuclear transfer (SCNT) in the human and subhuman primate relative to other mammals has been questioned for a variety of technical and logistical issues. Here we summarize the gradual evolution of SCNT technology from the perspective of oocyte quality and cell cycle status that has recently led to the demonstration of feasibility in the human for deriving chromosomally normal stem cells lines. With these advances in hand, prospects for therapeutic cloning must be entertained in a conscientious, rigorous, and timely fashion before broad spectrum clinical applications are undertaken.Entities:
Mesh：
Year: 2013 PMID： 23881160 PMCID： PMC3790123 DOI： 10.1007/s10815-013-0053-7
Source DB: PubMed Journal: J Assist Reprod Genet ISSN： 1058-0468 Impact factor: 3.412