BACKGROUND: High sensitivity C-reactive protein (hsCRP) is an acute phase reactant and a sensitive marker of inflammation. Age and adiposity can potentially promote the production of C-reactive protein (CRP). However, only a few studies have investigated any interaction between age and adiposity on hsCRP concentrations. METHODS: We recruited 822 men (mean age, 61 ± 14 years) and 1097 women (63 ± 12 years) during their annual health examination from a single community. We cross-sectionally examined whether age, body mass index (BMI), and the interaction are significantly associated with hsCRP concentrations, independent of confounding factors. RESULTS: Multiple linear regression analyses for hsCRP showed that in men, age (β = 0.169, P < 0.001) and BMI (β = 0.114, P = 0.004) as well as smoking status, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), uric acid, and gamma-glutamyl transferase (GGT) were significantly associated with hsCRP; and in women, age (β = 0.203, P < 0.001) and BMI (β = 0.225, P < 0.001) as well as HDL-C, fasting plasma glucose (FPG), uric acid, GGT and high-molecular weight adiponectin were significantly associated with hsCRP. In addition to their direct associations, the interaction between age and BMI was also a significant and independent determinant for hsCRP in both men (F = 4.407, P = 0.036) and women (F = 5.487, P = 0.019). In participants aged < 75 years, overweight (BMI ≥ 25.0 kg/m(2)) persons were more likely to have a prevalence of elevated hsCRP concentrations (≥ 1.00 mg/L) compared with the normal-weight (BMI <22.0 kg/m(2)), but such an association was not observed in those aged ≥ 75 years. CONCLUSIONS: Adiposity promotes low-grade systemic inflammation in community-dwelling persons aged <75 years.
BACKGROUND: High sensitivity C-reactive protein (hsCRP) is an acute phase reactant and a sensitive marker of inflammation. Age and adiposity can potentially promote the production of C-reactive protein (CRP). However, only a few studies have investigated any interaction between age and adiposity on hsCRP concentrations. METHODS: We recruited 822 men (mean age, 61 ± 14 years) and 1097 women (63 ± 12 years) during their annual health examination from a single community. We cross-sectionally examined whether age, body mass index (BMI), and the interaction are significantly associated with hsCRP concentrations, independent of confounding factors. RESULTS: Multiple linear regression analyses for hsCRP showed that in men, age (β = 0.169, P < 0.001) and BMI (β = 0.114, P = 0.004) as well as smoking status, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), uric acid, and gamma-glutamyl transferase (GGT) were significantly associated with hsCRP; and in women, age (β = 0.203, P < 0.001) and BMI (β = 0.225, P < 0.001) as well as HDL-C, fasting plasma glucose (FPG), uric acid, GGT and high-molecular weight adiponectin were significantly associated with hsCRP. In addition to their direct associations, the interaction between age and BMI was also a significant and independent determinant for hsCRP in both men (F = 4.407, P = 0.036) and women (F = 5.487, P = 0.019). In participants aged < 75 years, overweight (BMI ≥ 25.0 kg/m(2)) persons were more likely to have a prevalence of elevated hsCRP concentrations (≥ 1.00 mg/L) compared with the normal-weight (BMI <22.0 kg/m(2)), but such an association was not observed in those aged ≥ 75 years. CONCLUSIONS: Adiposity promotes low-grade systemic inflammation in community-dwelling persons aged <75 years.
Entities:
Keywords:
C-reactive protein; age; body mass index; gender; interaction
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