Literature DB >> 23880538

Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.

Philip Magnus1, Bahman Ghavimi, Jotham W Coe.   

Abstract

(-)-Codeine 1 was converted into previously unknown 7β-methyl-7,8-dihydrocodeine/morphine derivatives such as 13 via classical diaxial opening of α-epoxide 3. Several analogs exhibited dual μ/δ-agonist activity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  6,7-α-Epoxide; Metopon; Mixed μ/δ agonist; Opioid

Mesh：

Substances：

Year:  2013        PMID： 23880538     DOI： 10.1016/j.bmcl.2013.06.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.

Authors:  Wei Lei; Rakesh H Vekariya; Subramaniam Ananthan; John M Streicher
Journal:  J Pain       Date:  2019-06-12       Impact factor: 5.820

2.  Codeine Precipitating Serotonin Syndrome in a Patient in Therapy with Antidepressant and Triptan.

Authors:  Giulia Milano; Werner Maria Natta; Alfredo Bello; Antonietta Martelli; Francesca Mattioli
Journal:  Clin Psychopharmacol Neurosci       Date:  2017-08-31       Impact factor: 2.582
  2 in total

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