| Literature DB >> 23880088 |
Alexandre F Leitão1, Swati Gupta2, João Pedro Silva3, Ilya Reviakine4, Miguel Gama5.
Abstract
Bacterial cellulose (BC) has been suggested to be a suitable biomaterial for the development of cardiovascular grafts. The combination of BC with polyvinyl alcohol (PVA) results in nanocomposites with improved properties. Surprisingly, there are very few studies on the BC-blood interaction. This is the focus of this paper. We present the first thorough assessment of the hemocompatibility of the BC/PVA nanocomposite. Whole blood clotting time, plasma recalcification, Factor XII activation, platelet adhesion and activation, hemolytic index and complement activation are all determined. The platelet activation profiles on BC and BC/PVA surfaces are comprehensively characterized. BC and BC/PVA outperformed ePTFE--used as a point of comparison--thus evidencing their suitability for cardiovascular applications.Entities:
Keywords: Bacterial cellulose; Biocompatibility; Biomaterials; Hemocompatibility; Platelets; Polyvinyl alcohol
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Year: 2013 PMID: 23880088 DOI: 10.1016/j.colsurfb.2013.06.031
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN: 0927-7765 Impact factor: 5.268