BACKGROUND: Impulsive behavior and poor sleep are important non-motor features of Parkinson's disease (PD) that negatively impact the quality of life of patients and their families. Previous research suggests a higher level of sleep complaints in PD patients who demonstrate impulsive behaviors, but the nature of the sleep disturbances has yet to be comprehensively tested. METHODS: Consecutive idiopathic PD patients (N = 143) completed the Minnesota Impulse Disorder Interview and a sleep questionnaire that assessed sleep efficiency, excessive daytime sleepiness, restless legs symptoms, snoring, dreams/nightmares, and nocturia. Patients were also given a Unified Parkinson's Disease Rating Scale motor examination and they completed cognitive testing. RESULTS: Impulsive PD patients endorsed more sleep complaints than non-impulsive PD patients. The group difference was primarily attributable to poor sleep efficiency (e.g., greater nocturnal awakenings), p < .01, and greater daytime sleepiness, p < .01, in the impulsive PD patients. Interestingly, restless legs symptoms were also greater in the impulsive PD patients, p < .05. The results could not be explained by medications or disease severity. CONCLUSIONS: Poor sleep efficiency, restless legs symptoms, and increased daytime sleepiness are associated with impulsivity in PD. Longitudinal studies are needed to determine whether sleep disturbances precede impulsivity in PD.
BACKGROUND:Impulsive behavior and poor sleep are important non-motor features of Parkinson's disease (PD) that negatively impact the quality of life of patients and their families. Previous research suggests a higher level of sleep complaints in PDpatients who demonstrate impulsive behaviors, but the nature of the sleep disturbances has yet to be comprehensively tested. METHODS: Consecutive idiopathic PDpatients (N = 143) completed the Minnesota Impulse Disorder Interview and a sleep questionnaire that assessed sleep efficiency, excessive daytime sleepiness, restless legs symptoms, snoring, dreams/nightmares, and nocturia. Patients were also given a Unified Parkinson's Disease Rating Scale motor examination and they completed cognitive testing. RESULTS:Impulsive PDpatients endorsed more sleep complaints than non-impulsive PDpatients. The group difference was primarily attributable to poor sleep efficiency (e.g., greater nocturnal awakenings), p < .01, and greater daytime sleepiness, p < .01, in the impulsive PDpatients. Interestingly, restless legs symptoms were also greater in the impulsive PDpatients, p < .05. The results could not be explained by medications or disease severity. CONCLUSIONS:Poor sleep efficiency, restless legs symptoms, and increased daytime sleepiness are associated with impulsivity in PD. Longitudinal studies are needed to determine whether sleep disturbances precede impulsivity in PD.
Authors: Valerie Voon; Mandy Sohr; Anthony E Lang; Marc N Potenza; Andrew D Siderowf; Jacqueline Whetteckey; Daniel Weintraub; Glen R Wunderlich; Mark Stacy Journal: Ann Neurol Date: 2011-03-17 Impact factor: 10.422
Authors: Sean S O'Sullivan; Clare M Loane; Andrew D Lawrence; Andrew H Evans; Paola Piccini; Andrew J Lees Journal: J Neurol Neurosurg Psychiatry Date: 2010-06-20 Impact factor: 10.154
Authors: Donald L Bliwise; Lynn Marie Trotti; Anthony G Wilson; Sophia A Greer; Cathy Wood-Siverio; Jorge J Juncos; Stewart A Factor; Alan Freeman; David B Rye Journal: Mov Disord Date: 2012-07-02 Impact factor: 10.338
Authors: Taye H Hamza; Cyrus P Zabetian; Albert Tenesa; Alain Laederach; Jennifer Montimurro; Dora Yearout; Denise M Kay; Kimberly F Doheny; Justin Paschall; Elizabeth Pugh; Victoria I Kusel; Randall Collura; John Roberts; Alida Griffith; Ali Samii; William K Scott; John Nutt; Stewart A Factor; Haydeh Payami Journal: Nat Genet Date: 2010-08-15 Impact factor: 38.330
Authors: Robert S Eisinger; Adolfo Ramirez-Zamora; Samuel Carbunaru; Brandon Ptak; Zhongxing Peng-Chen; Michael S Okun; Aysegul Gunduz Journal: Front Neurol Date: 2019-02-26 Impact factor: 4.003
Authors: Alice Martini; Simon J Ellis; James A Grange; Stefano Tamburin; Denise Dal Lago; Greta Vianello; Nicola M J Edelstyn Journal: J Neural Transm (Vienna) Date: 2017-11-08 Impact factor: 3.575
Authors: Samuel Carbunaru; Robert S Eisinger; Adolfo Ramirez-Zamora; Dana Bassan; Amin Cervantes-Arriaga; Mayela Rodriguez-Violante; Daniel Martinez-Ramirez Journal: Brain Behav Date: 2018-02-10 Impact factor: 2.708