Literature DB >> 23877789

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform.

Anita Gianella1, Aneta J Mieszawska, Freek J M Hoeben, Henk M Janssen, Peter A Jarzyna, David P Cormode, Kevin D Costa, Satish Rao, Omid C Farokhzad, Robert Langer, Zahi A Fayad, Willem J M Mulder.   

Abstract

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

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Year:  2013        PMID： 23877789      PMCID： PMC3786364          DOI： 10.1039/c3cc43618g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.

Authors:  C Chang; Z Werb
Journal:  Trends Cell Biol       Date:  2001-11       Impact factor: 20.808

Review 2.  Long-circulating and target-specific nanoparticles: theory to practice.

Authors:  S M Moghimi; A C Hunter; J C Murray
Journal:  Pharmacol Rev       Date:  2001-06       Impact factor: 25.468

3.  Proteolytic actuation of nanoparticle self-assembly.

Authors:  Todd J Harris; Geoffrey von Maltzahn; Austin M Derfus; Erkki Ruoslahti; Sangeeta N Bhatia
Journal:  Angew Chem Int Ed Engl       Date:  2006-05-05       Impact factor: 15.336

Review 4.  Perspectives and opportunities for nanomedicine in the management of atherosclerosis.

Authors:  Mark E Lobatto; Valentin Fuster; Zahi A Fayad; Willem J M Mulder
Journal:  Nat Rev Drug Discov       Date:  2011-10-21       Impact factor: 84.694

5.  MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle.

Authors:  Willem J M Mulder; Gustav J Strijkers; Jo W Habets; Egbert J W Bleeker; Daisy W J van der Schaft; Gert Storm; Gerben A Koning; Arjan W Griffioen; Klaas Nicolay
Journal:  FASEB J       Date:  2005-10-04       Impact factor: 5.191

6.  MMP-2 protein in invasive breast cancer and the impact of MMP-2/TIMP-2 phenotype on overall survival.

Authors:  Lydia Nakopoulou; Ioanna Tsirmpa; Paraskevi Alexandrou; Androniki Louvrou; Constantine Ampela; Sophia Markaki; Panayiotis S Davaris
Journal:  Breast Cancer Res Treat       Date:  2003-01       Impact factor: 4.872

7.  Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging.

Authors:  Peter A Jarzyna; Torjus Skajaa; Anita Gianella; David P Cormode; Daniel D Samber; Stephen D Dickson; Wei Chen; Arjan W Griffioen; Zahi A Fayad; Willem J M Mulder
Journal:  Biomaterials       Date:  2009-09-23       Impact factor: 12.479

8.  Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions.

Authors:  Z Li; L Li; H R Zielke; L Cheng; R Xiao; M T Crow; W G Stetler-Stevenson; J Froehlich; E G Lakatta
Journal:  Am J Pathol       Date:  1996-01       Impact factor: 4.307

Review 9.  Nanocarriers as an emerging platform for cancer therapy.

Authors:  Dan Peer; Jeffrey M Karp; Seungpyo Hong; Omid C Farokhzad; Rimona Margalit; Robert Langer
Journal:  Nat Nanotechnol       Date:  2007-12       Impact factor: 39.213

10.  Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.

Authors:  Patrick M Winter; Shelton D Caruthers; Andrea Kassner; Thomas D Harris; Lori K Chinen; John S Allen; Elizabeth K Lacy; Huiying Zhang; J David Robertson; Samuel A Wickline; Gregory M Lanza
Journal:  Cancer Res       Date:  2003-09-15       Impact factor: 12.701
  10 in total
  5 in total

Review 1.  "Eat me" imaging and therapy.

Authors:  Vaishali Bagalkot; Jeffrey A Deiuliis; Sanjay Rajagopalan; Andrei Maiseyeu
Journal:  Adv Drug Deliv Rev       Date:  2016-01-27       Impact factor: 15.470

2.  Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.

Authors:  Francois Fay; Line Hansen; Stefanie J C G Hectors; Brenda L Sanchez-Gaytan; Yiming Zhao; Jun Tang; Jazz Munitz; Amr Alaarg; Mounia S Braza; Anita Gianella; Stuart A Aaronson; Thomas Reiner; Jørgen Kjems; Robert Langer; Freek J M Hoeben; Henk M Janssen; Claudia Calcagno; Gustav J Strijkers; Zahi A Fayad; Carlos Pérez-Medina; Willem J M Mulder
Journal:  Bioconjug Chem       Date:  2017-05-05       Impact factor: 4.774

3.  Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression.

Authors:  Irene C Turnbull; Ahmed A Eltoukhy; Kenneth M Fish; Mathieu Nonnenmacher; Kiyotake Ishikawa; Jiqiu Chen; Roger J Hajjar; Daniel G Anderson; Kevin D Costa
Journal:  Mol Ther       Date:  2015-10-16       Impact factor: 11.454

4.  CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging.

Authors:  Juan Gallo; Nazila Kamaly; Ioannis Lavdas; Elizabeth Stevens; Quang-De Nguyen; Marzena Wylezinska-Arridge; Eric O Aboagye; Nicholas J Long
Journal:  Angew Chem Int Ed Engl       Date:  2014-07-15       Impact factor: 15.336

Review 5.  Design considerations for nanotherapeutics in oncology.

Authors:  Triantafyllos Stylianopoulos; Rakesh K Jain
Journal:  Nanomedicine       Date:  2015-08-15       Impact factor: 5.307
  5 in total

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