Squamous cell carcinoma of the prostate with strong FDG uptake on PET/CT.

Primary squamous cell carcinoma (SCC) of the prostate is a rare aggressive neoplasm with a poor prognosis. A 60-year-old man presented with urinary frequency and interrupted urination for 4 months. Serum prostate-specific antigen and SCC antigen were elevated. T2-weighted MR images showed a hyperintense lesion in the central area of the prostate. FDG PET/CT showed strong FDG uptake of the lesion with SUVmax of 15.5. Prostate biopsy revealed moderate differentiated SCC. This case indicates SCC of the prostate should be considered in the differential diagnosis of abnormal prostate FDG accumulation (especially with elevated SCC antigen level).