Literature DB >> 23877238

Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.

Phuong Thien Thuong1, Tran Manh Hung, Nguyen Minh Khoi, Hoang Thi My Nhung, Nguyen Thi Chinh, Nguyen Thi Quy, Tae Su Jang, Minkyun Na.   

Abstract

Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.

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Year:  2013        PMID： 23877238     DOI： 10.1007/s12272-013-0185-4

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  4 in total

1.  Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease.

Authors:  Liang Gu; Nan Cai; Meiting Li; Decheng Bi; Lijun Yao; Weishan Fang; Yan Wu; Zhangli Hu; Qiong Liu; Zhijian Lin; Jun Lu; Xu Xu
Journal:  Front Nutr       Date:  2022-05-18

2.  A Comparative Pharmacokinetic Study of Myrislignan by UHPLC-MS After Oral Administration of a Monomer and Myristica fragrans Extract to Rats.

Authors:  Zhe Zhu; Shu Yang; Waiou Zhao; Rui Li; Chengliang Zhao
Journal:  J Chromatogr Sci       Date:  2016-01-15       Impact factor: 1.618

3.  Exploring in vitro anti-proliferative and anti-inflammatory activities of Prasachandaeng remedy, and its bioactive compounds.

Authors:  Nuntika Prommee; Arunporn Itharat; Pakakrong Thongdeeying; Sunita Makchuchit; Weerachai Pipatrattanaseree; Adis Tasanarong; Buncha Ooraikul; Neal M Davies
Journal:  BMC Complement Med Ther       Date:  2022-08-11

4.  Gehua Jiecheng Decoction Inhibits Diethylnitrosamine-Induced Hepatocellular Carcinoma in Mice by Improving Tumor Immunosuppression Microenvironment.

Authors:  Changpei Cheng; Qiyang Shou; Jiali Lang; Lu Jin; Xia Liu; Dongxin Tang; Zhu Yang; Huiying Fu
Journal:  Front Pharmacol       Date:  2020-05-29       Impact factor: 5.810
  4 in total

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