Literature DB >> 23876621

Telomerase at the intersection of cancer and aging.

Bruno Bernardes de Jesus1, Maria A Blasco.   

Abstract

Although cancer and aging have been studied as independent diseases, mounting evidence suggests that cancer is an aging-associated disease and that cancer and aging share many molecular pathways. In particular, recent studies validated telomerase activation as a potential therapeutic target for age-related diseases; in addition, abnormal telomerase expression and telomerase mutations have been associated with many different types of human tumor. Here, we revisit the connection between telomerase and cancer and aging in light of recent findings supporting a role for telomerase not only in telomere elongation, but also in metabolic fitness and Wnt activation. Understanding the physiological impact of telomerase regulation is fundamental given the therapeutic strategies that are being developed that involve telomerase modulation.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  aging; cancer; telomerase

Mesh：

Substances：

Year:  2013        PMID： 23876621      PMCID： PMC3896987          DOI： 10.1016/j.tig.2013.06.007

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  133 in total

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4.  The rate of increase of short telomeres predicts longevity in mammals.

Authors:  Elsa Vera; Bruno Bernardes de Jesus; Miguel Foronda; Juana M Flores; Maria A Blasco
Journal:  Cell Rep       Date:  2012-09-27       Impact factor: 9.423

5.  Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

Authors:  E González-Suárez; E Samper; J M Flores; M A Blasco
Journal:  Nat Genet       Date:  2000-09       Impact factor: 38.330

6.  Stem cell depletion in Hutchinson-Gilford progeria syndrome.

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Journal:  Aging Cell       Date:  2011-10-11       Impact factor: 9.304

7.  Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects.

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8.  Telomerase reverse transcriptase delays aging in cancer-resistant mice.

Authors:  Antonia Tomás-Loba; Ignacio Flores; Pablo J Fernández-Marcos; María L Cayuela; Antonio Maraver; Agueda Tejera; Consuelo Borrás; Ander Matheu; Peter Klatt; Juana M Flores; José Viña; Manuel Serrano; Maria A Blasco
Journal:  Cell       Date:  2008-11-14       Impact factor: 41.582

9.  Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.

Authors:  Elsa Vera; Bruno Bernardes de Jesus; Miguel Foronda; Juana M Flores; Maria A Blasco
Journal:  PLoS One       Date:  2013-01-22       Impact factor: 3.240

10.  Short telomeres initiate telomere recombination in primary and tumor cells.

Authors:  Tammy A Morrish; Carol W Greider
Journal:  PLoS Genet       Date:  2009-01-30       Impact factor: 5.917
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  68 in total

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Authors:  Pei-Tzu Li; Zi-Fu Wang; I-Te Chu; Yen-Min Kuan; Ming-Hao Li; Mu-Ching Huang; Pei-Chi Chiang; Ta-Chau Chang; Chin-Tin Chen
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Review 4.  Integrative structural biology of Tetrahymena telomerase - insights into catalytic mechanism and interaction at telomeres.

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Review 5.  Radiopharmaceuticals as probes to characterize tumour tissue.

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Review 6.  Progress in structural studies of telomerase.

Authors:  Edward J Miracco; Jiansen Jiang; Darian D Cash; Juli Feigon
Journal:  Curr Opin Struct Biol       Date:  2014-02-04       Impact factor: 6.809

7.  TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker.

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8.  In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

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9.  Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

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Review 10.  Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.

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