Literature DB >> 23876028

Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes.

Fernanda Fonseca-Silva1, Job D F Inacio, Marilene M Canto-Cavalheiro, Elmo E Almeida-Amaral.   

Abstract

The present study reports the mechanism of the antileishmanial activity of quercetin against the intracellular amastigote form of Leishmania amazonensis. Treatment with 1 reduced the infection index in L. amazonensis-infected macrophages in a dose-dependent manner, with an IC₅₀ value of 3.4 μM and a selectivity index of 16.8, and additionally increased ROS generation also in a dose-dependent manner. Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death. Taken together, these results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis.

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Year:  2013        PMID： 23876028     DOI： 10.1021/np400193m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

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2.  The effect of (-)-epigallocatechin 3-O--gallate in vitro and in vivo in Leishmania braziliensis: involvement of reactive oxygen species as a mechanism of action.

Authors:  Job D F Inacio; Luiza Gervazoni; Marilene M Canto-Cavalheiro; Elmo E Almeida-Amaral
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3.  Comparative in vitro toxicity of a graphene oxide-silver nanocomposite and the pristine counterparts toward macrophages.

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Journal:  J Nanobiotechnology       Date:  2016-02-24       Impact factor: 10.435

4.  Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action.

Authors:  Fernanda Fonseca-Silva; Job D F Inacio; Marilene M Canto-Cavalheiro; Rubem F S Menna-Barreto; Elmo E Almeida-Amaral
Journal:  PLoS Negl Trop Dis       Date:  2016-02-10

5.  Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection.

Authors:  Filipe Marques; Sílvia Vale-Costa; Tânia Cruz; Joana Moreira Marques; Tânia Silva; João Vilares Neves; Sofia Cortes; Ana Fernandes; Eduardo Rocha; Rui Appelberg; Pedro Rodrigues; Ana M Tomás; Maria Salomé Gomes
Journal:  Parasit Vectors       Date:  2015-12-18       Impact factor: 3.876

6.  2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis.

Authors:  Luiza F O Gervazoni; Gabriella Gonçalves-Ozório; Elmo E Almeida-Amaral
Journal:  PLoS Negl Trop Dis       Date:  2018-12-06

7.  Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis.

Authors:  Alireza Badirzadeh; Maryam Heidari-Kharaji; Vahid Fallah-Omrani; Hossein Dabiri; Atefeh Araghi; Alireza Salimi Chirani
Journal:  PLoS Negl Trop Dis       Date:  2020-01-13

Review 8.  Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise.

Authors:  Nicola S Carter; Brendan D Stamper; Fawzy Elbarbry; Vince Nguyen; Samuel Lopez; Yumena Kawasaki; Reyhaneh Poormohamadian; Sigrid C Roberts
Journal:  Microorganisms       Date:  2021-01-28

9.  Amentoflavone as an Ally in the Treatment of Cutaneous Leishmaniasis: Analysis of Its Antioxidant/Prooxidant Mechanisms.

Authors:  Yasmin Silva Rizk; Sandy Santos-Pereira; Luiza Gervazoni; Daiana de Jesus Hardoim; Flávia de Oliveira Cardoso; Celeste da Silva Freitas de Souza; Marcelo Pelajo-Machado; Carlos Alexandre Carollo; Carla Cardozo Pinto de Arruda; Elmo Eduardo Almeida-Amaral; Tânia Zaverucha-do-Valle; Kátia da Silva Calabrese
Journal:  Front Cell Infect Microbiol       Date:  2021-02-25       Impact factor: 5.293

Review 10.  Use of Natural Products in Leishmaniasis Chemotherapy: An Overview.

Authors:  Luiza F O Gervazoni; Gabrielle B Barcellos; Taiana Ferreira-Paes; Elmo E Almeida-Amaral
Journal:  Front Chem       Date:  2020-11-23       Impact factor: 5.221
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