AIM: The purpose of the present study was to evaluate the diagnostic value of maternal serum high-sensitivity C-reactive protein (hs-CRP) measurement during the first trimester of pregnancy for predicting pre-eclampsia. MATERIAL AND METHODS: A prospective cohort study was performed on 394 pregnant women who were at the gestational age of 8-13 weeks. In all women, serum hs-CRP was measured by latex agglutination test. The women were then monitored to delivery. We compared the hs-CRP of the two groups, those with and without pre-eclampsia. We used the receiver-operator curve for finding the optimum cut-off points. RESULTS: Out of 394 women, 42 cases (10.7%) were complicated by pre-eclampsia, of whom 23 women (56.1%) had severe pre-eclampsia. Mean serum hs-CRP of the pre-eclamptic group was higher than that of the normotensive group (7.06 ± 2.6 mg/L vs 3.6 ± 2.3 mg/L, P = 0.001). The receiver-operator curve showed a significant difference between the under-curve zone for the hs-CRP level with the reference line. Serum hs-CRP of 4 mg/L showed sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy as 78.1%, 72.1%, 25%, 96.5% and 72.8%, respectively. Hs-CRP of more than 7 mg/L was found in 26 (61.9%) cases of pre-eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (P = 0.001, relative risk = 12.1, 95% confidence interval: 6.91-21.15). Hs-CRP of more than 7 mg/L was found in 17 (73.91%) cases of severe pre-eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (P = 0.001, relative risk = 9.35, 95% confidence interval: 4.48-19.52). CONCLUSION: Hs-CRP measurements during the first trimester of pregnancy are helpful in predicting pre-eclampsia.
AIM: The purpose of the present study was to evaluate the diagnostic value of maternal serum high-sensitivity C-reactive protein (hs-CRP) measurement during the first trimester of pregnancy for predicting pre-eclampsia. MATERIAL AND METHODS: A prospective cohort study was performed on 394 pregnant women who were at the gestational age of 8-13 weeks. In all women, serum hs-CRP was measured by latex agglutination test. The women were then monitored to delivery. We compared the hs-CRP of the two groups, those with and without pre-eclampsia. We used the receiver-operator curve for finding the optimum cut-off points. RESULTS: Out of 394 women, 42 cases (10.7%) were complicated by pre-eclampsia, of whom 23 women (56.1%) had severe pre-eclampsia. Mean serum hs-CRP of the pre-eclamptic group was higher than that of the normotensive group (7.06 ± 2.6 mg/L vs 3.6 ± 2.3 mg/L, P = 0.001). The receiver-operator curve showed a significant difference between the under-curve zone for the hs-CRP level with the reference line. Serum hs-CRP of 4 mg/L showed sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy as 78.1%, 72.1%, 25%, 96.5% and 72.8%, respectively. Hs-CRP of more than 7 mg/L was found in 26 (61.9%) cases of pre-eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (P = 0.001, relative risk = 12.1, 95% confidence interval: 6.91-21.15). Hs-CRP of more than 7 mg/L was found in 17 (73.91%) cases of severe pre-eclampsia and 22 (6.25%) normotensive pregnancies, which showed a significant difference (P = 0.001, relative risk = 9.35, 95% confidence interval: 4.48-19.52). CONCLUSION: Hs-CRP measurements during the first trimester of pregnancy are helpful in predicting pre-eclampsia.
Authors: Cassandra N Spracklen; Caitlin J Smith; Audrey F Saftlas; Elizabeth W Triche; Andrew Bjonnes; Brendan J Keating; Richa Saxena; Patrick J Breheny; Andrew T Dewan; Jennifer G Robinson; Josephine Hoh; Kelli K Ryckman Journal: Hypertens Pregnancy Date: 2016-09-22 Impact factor: 2.108
Authors: Priscila E Parra-Pingel; Luis A Quisiguiña-Avellán; Luis Hidalgo; Peter Chedraui; Faustino R Pérez-López Journal: Adolesc Health Med Ther Date: 2017-06-06
Authors: Anaelechi J Onuegbu; Japhet M Olisekodiaka; John U Udo; Osita Umeononihu; Ubuoh K Amah; John E Okwara; Chidiadi Atuegbu Journal: Med Princ Pract Date: 2015-04-21 Impact factor: 1.927
Authors: Tracy L Schumacher; Christopher Oldmeadow; Don Clausen; Loretta Weatherall; Lyniece Keogh; Kirsty G Pringle; Kym M Rae Journal: Healthcare (Basel) Date: 2017-10-14