| Literature DB >> 23875832 |
James P Hall1, Daniel Cook, Sara Ruiz Morte, Patrick McIntyre, Katrin Buchner, Hanna Beer, David J Cardin, John A Brazier, Graeme Winter, John M Kelly, Christine J Cardin.
Abstract
We report an atomic resolution X-ray crystal structure containing both enantiomers of rac-[Ru(phen)2dppz](2+) with the d(ATGCAT)2 DNA duplex (phen = phenanthroline; dppz = dipyridophenazine). The first example of any enantiomeric pair crystallized with a DNA duplex shows different orientations of the Λ and Δ binding sites, separated by a clearly defined structured water monolayer. Job plots show that the same species is present in solution. Each enantiomer is bound at a TG/CA step and shows intercalation from the minor groove. One water molecule is directly located on one phenazine N atom in the Δ-enantiomer only.Entities:
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Year: 2013 PMID： 23875832 DOI： 10.1021/ja403590e
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419