TO THE EDITOR: While reporting the complexity behind the interpretation of the manometric trace of the upper esophageal sphincter (UES), Bhatia and Shah1 wrote: "It is a technically demanding procedure due to the anatomy of the UES, as is the movement of the sphincter during swallowing."We agree with the authors that some of the difficulties are due to the movement of the sphincter during swallowing. This is proved by the fact that for example the contraction of the sphincter is still referred to by many different terms, including "closing tone, closing phase, sphincter contraction and post-swallow UES contraction etc."They nicely showed the limitations of manometry. They reported that "The parameters which are most evaluated are baseline UES pressure, UES relaxation time, nadir pressure during UES relaxation, UES co-ordination with pharyngeal contraction, amplitude of pharyngeal contraction and intrabolus pressure." These are well-established factors associated with motility abnormalities of the UES.2-4So, to ask an old question, how should the UES manometry be interpreted? To give a contribution to the UES motility, we have recently reviewed our experience, and have stressed the fact that scientists are likely to focus only on the co-ordination between the pharynx and the UES and often disregard the co-ordination of the UES with the upper esophageal contraction (called crico-esophageal coordination).5 We dissected the manometry of the UES into a two-phase waveform. The first of relaxation is normal when it occurs before the onset of the pharyngeal contraction while the second phase of contraction is normal when the peak of UES contraction precedes the peak of the UE contraction. The correlation between the UES and the upper esophagus has been demonstrated also using different methodologies such as histochemical analysis,6 biomechanical markers and electromyographic study. The analysis of the crico-esophageal coordination permitted us to identify abnormalities in several patients suffering from high dysphagia that would have been remained undiagnosed. Crico-esophageal abnormalities have been found in patients with Zenker diverticulum,7 tight Nissen8 and achalasia of the LES.9 A new classification of the pharyngo-esophageal motility disorders was proposed: pharyngeal (pre-sphincteric), sphincteric and esophageal (post-sphincteric) disorders.10To conclude, although we also agree with the authors' final conclusion: "UES manometry is useful in the management of patients with dysphagia," we believe that for a more precise understanding of the UES disorders the study of the crico-esophageal coordination should be added. Further investigative work may be required in the evaluation of the UES.