Literature DB >> 2387399

Cloning of the human brain GABA transporter.

H Nelson1, S Mandiyan, N Nelson.   

Abstract

A cDNA clone encoding a transporter for the neurotransmitter gamma-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.

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Year:  1990        PMID： 2387399     DOI： 10.1016/0014-5793(90)81149-i

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

1.  Passive water and ion transport by cotransporters.

Authors:  D D Loo; B A Hirayama; A K Meinild; G Chandy; T Zeuthen; E M Wright
Journal:  J Physiol       Date:  1999-07-01       Impact factor: 5.182

Review 2.  Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6.

Authors:  Nian-Hang Chen; Maarten E A Reith; Michael W Quick
Journal:  Pflugers Arch       Date:  2003-04-29       Impact factor: 3.657

3.  Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

Authors:  Q R Liu; B López-Corcuera; H Nelson; S Mandiyan; N Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

4.  Identification and characterization of γ-aminobutyric acid uptake system GabPCg (NCgl0464) in Corynebacterium glutamicum.

Authors:  Zhi Zhao; Jiu-Yuan Ding; Wen-Hua Ma; Ning-Yi Zhou; Shuang-Jiang Liu
Journal:  Appl Environ Microbiol       Date:  2012-02-03       Impact factor: 4.792

5.  Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission.

Authors:  Einav Cohen-Kfir; William Lee; Sepehr Eskandari; Nathan Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-13       Impact factor: 11.205

Review 6.  Ligand-gated ion channels. Homology and diversity.

Authors:  V B Cockcroft; D J Osguthorpe; E A Barnard; A E Friday; G G Lunt
Journal:  Mol Neurobiol       Date:  1990 Fall-Winter       Impact factor: 5.590

7.  Turnover rate of the gamma-aminobutyric acid transporter GAT1.

Authors:  Albert L Gonzales; William Lee; Shelly R Spencer; Raymond A Oropeza; Jacqueline V Chapman; Jerry Y Ku; Sepehr Eskandari
Journal:  J Membr Biol       Date:  2007-11-09       Impact factor: 1.843

Review 8.  Role of GABA in the mechanism of the onset of puberty in non-human primates.

Authors:  Ei Terasawa
Journal:  Int Rev Neurobiol       Date:  2005       Impact factor: 3.230

9.  Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

Authors:  S Ramamoorthy; A L Bauman; K R Moore; H Han; T Yang-Feng; A S Chang; V Ganapathy; R D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

10.  Expression of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter in the rat retina.

Authors:  N C Brecha; C Weigmann
Journal:  J Comp Neurol       Date:  1994-07-22       Impact factor: 3.215
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