Literature DB >> 2387388

Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA.

E I Frolova1, E M Ivanova, V F Zarytova, T V Abramova, V V Vlassov.   

Abstract

Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.

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Year:  1990        PMID： 2387388     DOI： 10.1016/0014-5793(90)81129-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Sequence-dependent cleavage of DNA by alkylation with antisense oligodeoxyribonucleotides containing a 2-(N-iodoacetylaminoethyl)thio-adenine.

Authors:  K Kido; H Inoue; E Ohtsuka
Journal:  Nucleic Acids Res       Date:  1992-03-25       Impact factor: 16.971

2.  Preferential hydroxylation by the chemical nuclease meso-tetrakis-(4-N-methylpyridiniumyl)porphyrinatomanganeseIII pentaacetate/KHSO5 at the 5' carbon of deoxyriboses on both 3' sides of three contiguous A.T base pairs in short double-stranded oligonucleotides.

Authors:  M Pitié; G Pratviel; J Bernadou; B Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

3.  Influence of the nature of the porphyrin ligand on the nuclease activity of metalloporphyrin-oligonucleotide conjugates designed with cationic, hydrophobic or anionic metalloporphyrins.

Authors:  B Mestre; M Pitié; C Loup; C Claparols; G Pratviel; B Meunier
Journal:  Nucleic Acids Res       Date:  1997-03-01       Impact factor: 16.971

4.  Catalytic site-specific cleavage of a DNA-target by an oligonucleotide carrying bleomycin A5.

Authors:  D S Sergeyev; T S Godovikova; V F Zarytova
Journal:  Nucleic Acids Res       Date:  1995-11-11       Impact factor: 16.971
  4 in total

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