| Literature DB >> 23873506 |
Jiao Mo1, Pharkphoom Panichayupakaranant, Nattha Kaewnopparat, Sarunyoo Songkro, Wantana Reanmongkol.
Abstract
The present study evaluated the topical anti-inflammatory potential of a standardized pomegranate rind extracts (SPRE) in parallel with its marker compound ellagic acid (EA, 13% w/w) against a mouse model of contact dermatitis. In the phenol-induced mouse ear edema, topical application of SPRE (5, 2.5, and 1 mg/ear) and EA (0.65, 0.325, and 0.13 mg/ear, equivalent to its content in SPRE) dose-dependently reduced the ear edema with the maximal inhibition of 79.12% and 73.63%, respectively. Triamcinolone (0.1 mg/ear) and diclofenac (1 mg/ear) as reference drugs inhibited the edema by 73.63% and 37.91%. Myeloperoxidase (MPO) activity in the mouse ear was also decreased by SPRE and EA up to 69.68% and 68.79%, respectively. Triamcinolone and diclofenac decreased the MPO activity by 76.66% and 80.14% similarly. The results indicated that topical application of SPRE and EA is promising for use in the treatment of inflammatory skin disorders.Entities:
Keywords: Punica granatum; contact dermatitis; ellagic acid; inflammation; topical application
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Year: 2013 PMID： 23873506 DOI： 10.1002/ptr.5039
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878