Literature DB >> 23872847

Targeting H3K4 trimethylation in Huntington disease.

Malini Vashishtha1, Christopher W Ng, Ferah Yildirim, Theresa A Gipson, Ian H Kratter, Laszlo Bodai, Wan Song, Alice Lau, Adam Labadorf, Annie Vogel-Ciernia, Juan Troncosco, Christopher A Ross, Gillian P Bates, Dimitri Krainc, Ghazaleh Sadri-Vakili, Steven Finkbeiner, J Lawrence Marsh, David E Housman, Ernest Fraenkel, Leslie M Thompson.   

Abstract

Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin expression. Finally, reduction of SMCX/Jarid1c in primary neurons from BACHD mice or the single Jarid1 in a Drosophila HD model was protective. Therefore, targeting this epigenetic signature may be an effective strategy to ameliorate the consequences of HD.

Entities:  

Keywords:  neurodegeneration; polyglutamine

Mesh：

Substances：

Year:  2013        PMID： 23872847      PMCID： PMC3740882          DOI： 10.1073/pnas.1311323110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  55 in total

1.  The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Authors:  J S Steffan; A Kazantsev; O Spasic-Boskovic; M Greenwald; Y Z Zhu; H Gohler; E E Wanker; G P Bates; D E Housman; L M Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

2.  Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

Authors:  Ghazaleh Sadri-Vakili; Bérengère Bouzou; Caroline L Benn; Mee-Ohk Kim; Prianka Chawla; Ryan P Overland; Kelly E Glajch; Eva Xia; Zhihua Qiu; Steven M Hersch; Timothy W Clark; George J Yohrling; Jang-Ho J Cha
Journal:  Hum Mol Genet       Date:  2007-04-04       Impact factor: 6.150

3.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Authors:  Nathaniel D Heintzman; Rhona K Stuart; Gary Hon; Yutao Fu; Christina W Ching; R David Hawkins; Leah O Barrera; Sara Van Calcar; Chunxu Qu; Keith A Ching; Wei Wang; Zhiping Weng; Roland D Green; Gregory E Crawford; Bing Ren
Journal:  Nat Genet       Date:  2007-02-04       Impact factor: 38.330

4.  Histone methylation regulates memory formation.

Authors:  Swati Gupta; Se Y Kim; Sonja Artis; David L Molfese; Armin Schumacher; J David Sweatt; Richard E Paylor; Farah D Lubin
Journal:  J Neurosci       Date:  2010-03-10       Impact factor: 6.167

5.  Interaction of Huntington disease protein with transcriptional activator Sp1.

Authors:  Shi-Hua Li; Anna L Cheng; Hui Zhou; Suzanne Lam; Manjula Rao; He Li; Xiao-Jiang Li
Journal:  Mol Cell Biol       Date:  2002-03       Impact factor: 4.272

6.  Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Authors:  J S Steffan; L Bodai; J Pallos; M Poelman; A McCampbell; B L Apostol; A Kazantsev; E Schmidt; Y Z Zhu; M Greenwald; R Kurokawa; D E Housman; G R Jackson; J L Marsh; L M Thompson
Journal:  Nature       Date:  2001-10-18       Impact factor: 49.962

7.  Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues.

Authors:  Gilad Landan; Netta Mendelson Cohen; Zohar Mukamel; Amir Bar; Alina Molchadsky; Ran Brosh; Shirley Horn-Saban; Daniela Amann Zalcenstein; Naomi Goldfinger; Adi Zundelevich; Einav Nili Gal-Yam; Varda Rotter; Amos Tanay
Journal:  Nat Genet       Date:  2012-10-14       Impact factor: 38.330

8.  CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.

Authors:  Barbara L Apostol; Danielle A Simmons; Chiara Zuccato; Katalin Illes; Judit Pallos; Malcolm Casale; Paola Conforti; Catarina Ramos; Margaret Roarke; Satish Kathuria; Elena Cattaneo; J Lawrence Marsh; Leslie Michels Thompson
Journal:  Mol Cell Neurosci       Date:  2008-04-24       Impact factor: 4.314

9.  Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.

Authors:  C Zuccato; A Ciammola; D Rigamonti; B R Leavitt; D Goffredo; L Conti; M E MacDonald; R M Friedlander; V Silani; M R Hayden; T Timmusk; S Sipione; E Cattaneo
Journal:  Science       Date:  2001-06-14       Impact factor: 47.728

10.  ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity.

Authors:  Matthew D Young; Tracy A Willson; Matthew J Wakefield; Evelyn Trounson; Douglas J Hilton; Marnie E Blewitt; Alicia Oshlack; Ian J Majewski
Journal:  Nucleic Acids Res       Date:  2011-06-07       Impact factor: 16.971
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  61 in total

1.  Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.

Authors:  Emily Brookes; Benoit Laurent; Katrin Õunap; Renee Carroll; John B Moeschler; Michael Field; Charles E Schwartz; Jozef Gecz; Yang Shi
Journal:  Hum Mol Genet       Date:  2015-02-09       Impact factor: 6.150

Review 2.  Epigenetic Regulation in Neurodegenerative Diseases.

Authors:  Amit Berson; Raffaella Nativio; Shelley L Berger; Nancy M Bonini
Journal:  Trends Neurosci       Date:  2018-06-07       Impact factor: 13.837

Review 3.  JARID1 Histone Demethylases: Emerging Targets in Cancer.

Authors:  Kayla M Harmeyer; Nicole D Facompre; Meenhard Herlyn; Devraj Basu
Journal:  Trends Cancer       Date:  2017-09-12

4.  Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice.

Authors: 
Journal:  Nat Neurosci       Date:  2017-03-20       Impact factor: 24.884

5.  FACS-array-based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model.

Authors:  Haruko Miyazaki; Tomoyuki Yamanaka; Fumitaka Oyama; Yoshihiro Kino; Masaru Kurosawa; Mizuki Yamada-Kurosawa; Risa Yamano; Tomomi Shimogori; Nobutaka Hattori; Nobuyuki Nukina
Journal:  J Biol Chem       Date:  2020-06-04       Impact factor: 5.157

Review 6.  Epigenetic regulation of memory by acetylation and methylation of chromatin: implications in neurological disorders, aging, and addiction.

Authors:  Nilkantha Sen
Journal:  Neuromolecular Med       Date:  2014-04-29       Impact factor: 3.843

7.  Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.

Authors:  Erica Y Shen; Yan Jiang; Behnam Javidfar; Bibi Kassim; Yong-Hwee E Loh; Qi Ma; Amanda C Mitchell; Venu Pothula; A Francis Stewart; Patricia Ernst; Wei-Dong Yao; Gilles Martin; Li Shen; Mira Jakovcevski; Schahram Akbarian
Journal:  Neuropsychopharmacology       Date:  2016-08-03       Impact factor: 7.853

8.  Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice.

Authors:  Amanda J Kedaigle; Jack C Reidling; Ryan G Lim; Miriam Adam; Jie Wu; Brook Wassie; Jennifer T Stocksdale; Malcolm S Casale; Ernest Fraenkel; Leslie M Thompson
Journal:  Hum Mol Genet       Date:  2020-01-15       Impact factor: 6.150

9.  Linking epigenetic dysregulation, mitochondrial impairment, and metabolic dysfunction in SBMA motor neurons.

Authors:  Naemeh Pourshafie; Ester Masati; Eric Bunker; Alec R Nickolls; Parisorn Thepmankorn; Kory Johnson; Xia Feng; Tyler Ekins; Christopher Grunseich; Kenneth H Fischbeck
Journal:  JCI Insight       Date:  2020-07-09

10.  Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.

Authors:  Guang Bai; Iris Cheung; Hennady P Shulha; Joana E Coelho; Ping Li; Xianjun Dong; Mira Jakovcevski; Yumei Wang; Anastasia Grigorenko; Yan Jiang; Andrew Hoss; Krupal Patel; Ming Zheng; Evgeny Rogaev; Richard H Myers; Zhiping Weng; Schahram Akbarian; Jiang-Fan Chen
Journal:  Hum Mol Genet       Date:  2014-12-05       Impact factor: 6.150
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