OBJECTIVE: Since dual energy X-ray absorptiometry (DXA) cannot distinguish between different adipose tissue (AT) deposits, it remains unclear how DXA-derived body composition variables relate to anatomical tissue (sub)compartments. The aim of the present study was to compare and relate regional DXA variables with absolute tissue masses obtained by computer tomography (CT) scanning of the lower limbs in elderly persons. METHODS: Eleven well-preserved white Caucasian adults (seven male and four female cadavers) with a median age of 79.0 years (ranging from 68 to 96 years) were fully scanned with DXA and CT. Separate densities of skin tissue, AT, muscle tissue and bone were obtained by hydrostatic weighing. RESULTS: The leg DXA-variables were significantly related (rho-values between 0.60 and 0.98, P < 0.01) to CT-derived tissue counterparts, but showed significant systematic differences except for subcutaneous AT mass (P = 0.773). After controlling for other AT depots, fat as measured by DXA (fat(DXA)) related only to intermuscular AT (rho = 0.82, P < 0.01) in males and to subcutaneous AT (rho = 0.84, P < 0.05) in females. CONCLUSION: Although significantly interrelated, DXA and CT variables should not be used interchangeably since they have different quantitative and physiological significance. Our results suggest that fat(DXA) represents different parts of AT depots in elderly men and women. Since DXA is not appropriate for assessing tissue variability cautious clinical interpretation is warranted.
OBJECTIVE: Since dual energy X-ray absorptiometry (DXA) cannot distinguish between different adipose tissue (AT) deposits, it remains unclear how DXA-derived body composition variables relate to anatomical tissue (sub)compartments. The aim of the present study was to compare and relate regional DXA variables with absolute tissue masses obtained by computer tomography (CT) scanning of the lower limbs in elderly persons. METHODS: Eleven well-preserved white Caucasian adults (seven male and four female cadavers) with a median age of 79.0 years (ranging from 68 to 96 years) were fully scanned with DXA and CT. Separate densities of skin tissue, AT, muscle tissue and bone were obtained by hydrostatic weighing. RESULTS: The leg DXA-variables were significantly related (rho-values between 0.60 and 0.98, P < 0.01) to CT-derived tissue counterparts, but showed significant systematic differences except for subcutaneous AT mass (P = 0.773). After controlling for other AT depots, fat as measured by DXA (fat(DXA)) related only to intermuscular AT (rho = 0.82, P < 0.01) in males and to subcutaneous AT (rho = 0.84, P < 0.05) in females. CONCLUSION: Although significantly interrelated, DXA and CT variables should not be used interchangeably since they have different quantitative and physiological significance. Our results suggest that fat(DXA) represents different parts of AT depots in elderly men and women. Since DXA is not appropriate for assessing tissue variability cautious clinical interpretation is warranted.
Authors: Yubing Tong; Jayaram K Udupa; Drew A Torigian; Dewey Odhner; Caiyun Wu; Gargi Pednekar; Scott Palmer; Anna Rozenshtein; Melissa A Shirk; John D Newell; Mary Porteous; Joshua M Diamond; Jason D Christie; David J Lederer Journal: PLoS One Date: 2017-01-03 Impact factor: 3.240
Authors: Luis Henrique A Castro; Flávio Henrique S de Araújo; Mi Ye M Olimpio; Raquel B de B Primo; Thiago T Pereira; Luiz Augusto F Lopes; Erasmo B S de M Trindade; Ricardo Fernandes; Silvia A Oesterreich Journal: Nutrients Date: 2019-09-02 Impact factor: 5.717
Authors: Guadalupe Elizabeth Jimenez-Gutierrez; Laura Edith Martínez-Gómez; Carlos Martínez-Armenta; Carlos Pineda; Gabriela Angélica Martínez-Nava; Alberto Lopez-Reyes Journal: Cells Date: 2022-08-01 Impact factor: 7.666
Authors: Fanny Buckinx; Francesco Landi; Matteo Cesari; Roger A Fielding; Marjolein Visser; Klaus Engelke; Stefania Maggi; Elaine Dennison; Nasser M Al-Daghri; Sophie Allepaerts; Jurgen Bauer; Ivan Bautmans; Maria Luisa Brandi; Olivier Bruyère; Tommy Cederholm; Francesca Cerreta; Antonio Cherubini; Cyrus Cooper; Alphonso Cruz-Jentoft; Eugene McCloskey; Bess Dawson-Hughes; Jean-Marc Kaufman; Andrea Laslop; Jean Petermans; Jean-Yves Reginster; René Rizzoli; Sian Robinson; Yves Rolland; Ricardo Rueda; Bruno Vellas; John A Kanis Journal: J Cachexia Sarcopenia Muscle Date: 2018-01-19 Impact factor: 12.910