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Literature DB >> 23871222

Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents.

Abstract

Three-component coupling of aldehyde, 2-hydroxy-1,4-naphthoquinone and 3-amino-1,2,4-triazole has been achieved using a catalytic amount of sulfamic acid under solvent free conditions to produce a novel series of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-dione derivatives in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.

Entities: Chemical

Keywords: 2-Hydroxy-1,4-naphthoquinone; Aldehydes; Antitumor; Ortho-Naphthoquinone; Solvent-free; Sulfamic acid

Mesh：

Substances：

Year: 2013 PMID： 23871222 DOI： 10.1016/j.bmcl.2013.06.040

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

Review 1. α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

Authors: Shah Imtiaz; Jahangir Ahmad War; Syqa Banoo; Sarfaraz Khan
Journal: RSC Adv Date: 2021-03-16 Impact factor: 3.361

2. Application of polyionic magnetic nanoparticles as a catalyst for the synthesis of carbonitriles with both indole and triazole moieties via a cooperative geminal-vinylogous anomeric-based oxidation.

Authors: Mohammad Dashteh; Saeed Baghery; Mohammad Ali Zolfigol; Ardeshir Khazaei
Journal: Mol Divers Date: 2021-10-25 Impact factor: 3.364

Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents.

Review 1. α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

2. Application of polyionic magnetic nanoparticles as a catalyst for the synthesis of carbonitriles with both indole and triazole moieties via a cooperative geminal-vinylogous anomeric-based oxidation.

3. Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors.

4. Novel sulphonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers.

5. 3-Dialkylamino-1,2,4-triazoles via Zn^II-Catalyzed Acyl Hydrazide-Dialkylcyanamide Coupling.

Review 6. An insight on medicinal attributes of 1,2,4-triazoles.

Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents.

Review 1. α-Aminoazoles/azines: key reaction partners for multicomponent reactions.

2. Application of polyionic magnetic nanoparticles as a catalyst for the synthesis of carbonitriles with both indole and triazole moieties via a cooperative geminal-vinylogous anomeric-based oxidation.

3. Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors.

4. Novel sulphonamide benzoquinazolinones as dual EGFR/HER2 inhibitors, apoptosis inducers and radiosensitizers.

5. 3-Dialkylamino-1,2,4-triazoles via ZnII-Catalyzed Acyl Hydrazide-Dialkylcyanamide Coupling.

Review 6. An insight on medicinal attributes of 1,2,4-triazoles.

5. 3-Dialkylamino-1,2,4-triazoles via Zn^II-Catalyzed Acyl Hydrazide-Dialkylcyanamide Coupling.