Literature DB >> 23871159

Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells.

Tuoen Liu1, Zhiqiang Fei, Kalyan J Gangavarapu, Senyo Agbenowu, Alok Bhushan, James C K Lai, Christopher K Daniels, Shousong Cao.   

Abstract

We previously reported the establishment and characteristics of a DXM-resistant cell line (7TD1-DXM) generated from the IL6-dependent mouse B cell hybridoma, 7TD1 cell line. After withdrawing DXM from 7TD1-DXM cells over 90 days, DXM significantly inhibited the cell growth and induced apoptosis in the cells (7TD1-WD) compared with 7TD1-DXM cells. Additionally, IL-6 reversed while IL-6 antibody and AG490 enhanced the effects of growth inhibition and apoptosis induced by DXM in 7TD1-WD cells. Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AG490; Dexamethasone resistance; Dexamethasone withdrawal; Interleukin-6; JAK2/STAT3 signaling pathway; Multiple myeloma

Mesh：

Substances：

Year:  2013        PMID： 23871159      PMCID： PMC3769515          DOI： 10.1016/j.leukres.2013.06.026

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  50 in total

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