| Literature DB >> 23870987 |
Patrícia Costa1, Sandra Gonçalves, Patrícia Valentão, Paula B Andrade, Carlos Almeida, José M F Nogueira, Anabela Romano.
Abstract
We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe(2+) chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.Entities:
Keywords: 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation; 2,2′-azobis(2-methylpropionamidine) dihydrochloride; 5,5′-dithiobis [2-nitrobenzoic acid]; 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid; AAPH; ABTS(+); ACh; AChE; AD; ATCI; AUC; Alzheimer’s disease; Anti-cholinesterases; Antioxidants; Aβ; BChE; BHT; BTCI; DTNB; EDTA; Essential oil; GC–MS; HD; HPLC–DAD; Lavandula pedunculata subsp. lusitanica; MDA; ORAC; Phenolic compounds; SDS; TBA; TBARS; TE; TEAC; Trolox; Trolox equivalent antioxidant capacity; Trolox equivalents; acetylcholine; acetylcholinesterase; acetylthiocholine iodide; amyloid beta; area under the curve; butylated hydroxytoluene; butyrylcholinesterase; butyrylthiocholine chloride; ethylenediaminetetraacetic acid; gas chromatography–mass spectrometry; high-performance liquid chromatography–diode array detection; hydrodistillation; malondialdehyde; oxygen radical absorbance capacity; sodium dodecylsulphate; thiobarbituric acid; thiobarbituric acid-reactive substances
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Year: 2013 PMID： 23870987 DOI： 10.1016/j.foodchem.2013.05.055
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514