Literature DB >> 23868724

Polymers with tunable side-chain amphiphilicity as non-hemolytic antibacterial agents.

Divakara S S M Uppu1, Padma Akkapeddi, Goutham B Manjunath, Venkateswarlu Yarlagadda, Jiaul Hoque, Jayanta Haldar.   

Abstract

Quaternized polymers mimicking the antimicrobial peptides were created by tuning the side-chain amphiphilicity using a first-time approach of post-functionalization. They displayed excellent efficacy against pathogenic bacteria even in human plasma and membrane disruptive mode of action. The optimized polymers and degraded products were non-hemolytic.

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Year:  2013        PMID： 23868724     DOI： 10.1039/c3cc43751e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

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Authors:  Bo Ma; Chao Niu; Ying Zhou; Xiaoyan Xue; Jingru Meng; Xiaoxing Luo; Zheng Hou
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

2.  Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives.

Authors:  Zhi-Chen Wu; Dale L Boger
Journal:  Tetrahedron       Date:  2019-02-04       Impact factor: 2.457

3.  Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.

Authors:  Venkateswarlu Yarlagadda; Mohini M Konai; Goutham B Manjunath; Chandradhish Ghosh; Jayanta Haldar
Journal:  J Antibiot (Tokyo)       Date:  2014-10-29       Impact factor: 2.649

4.  Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus.

Authors:  Rajib Dey; Kathakali De; Riya Mukherjee; Sreyan Ghosh; Jayanta Haldar
Journal:  Medchemcomm       Date:  2019-07-30       Impact factor: 3.597

5.  Membrane-active macromolecules resensitize NDM-1 gram-negative clinical isolates to tetracycline antibiotics.

Authors:  Divakara S S M Uppu; Goutham B Manjunath; Venkateswarlu Yarlagadda; Jyothi E Kaviyil; Raju Ravikumar; Krishnamoorthy Paramanandham; Bibek R Shome; Jayanta Haldar
Journal:  PLoS One       Date:  2015-03-19       Impact factor: 3.240

6.  Antiviral Screening of Multiple Compounds against Ebola Virus.

Authors:  Stuart D Dowall; Kevin Bewley; Robert J Watson; Seshadri S Vasan; Chandradhish Ghosh; Mohini M Konai; Gro Gausdal; James B Lorens; Jason Long; Wendy Barclay; Isabel Garcia-Dorival; Julian Hiscox; Andrew Bosworth; Irene Taylor; Linda Easterbrook; James Pitman; Sian Summers; Jenny Chan-Pensley; Simon Funnell; Julia Vipond; Sue Charlton; Jayanta Haldar; Roger Hewson; Miles W Carroll
Journal:  Viruses       Date:  2016-10-27       Impact factor: 5.048

7.  Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria.

Authors:  Divakara S S M Uppu; Mohini M Konai; Paramita Sarkar; Sandip Samaddar; Isabel C M Fensterseifer; Celio Farias-Junior; Paramanandam Krishnamoorthy; Bibek R Shome; Octávio L Franco; Jayanta Haldar
Journal:  PLoS One       Date:  2017-08-24       Impact factor: 3.240

8.  Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity.

Authors:  Anjali Patel; Subhasis Dey; Kamal Shokeen; Tomasz M Karpiński; Senthilkumar Sivaprakasam; Sachin Kumar; Debasis Manna
Journal:  RSC Med Chem       Date:  2021-05-24

9.  Hydrophobicity and helicity regulate the antifungal activity of 14-helical β-peptides.

Authors:  Myung-Ryul Lee; Namrata Raman; Samuel H Gellman; David M Lynn; Sean P Palecek
Journal:  ACS Chem Biol       Date:  2014-06-02       Impact factor: 5.100

10.  Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid.

Authors:  Mitra S Ganewatta; Md Anisur Rahman; Louis Mercado; Tinom Shokfai; Alan W Decho; Theresa M Reineke; Chuanbing Tang
Journal:  Bioact Mater       Date:  2018-02-23
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