OBJECTIVES: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. METHODS: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. RESULTS: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. CONCLUSIONS: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.
OBJECTIVES: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons. METHODS: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength. RESULTS: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors. CONCLUSIONS: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.
Authors: V A Hughes; W R Frontera; M Wood; W J Evans; G E Dallal; R Roubenoff; M A Fiatarone Singh Journal: J Gerontol A Biol Sci Med Sci Date: 2001-05 Impact factor: 6.053
Authors: Connie M Weaver; Stephen Barnes; J Michael Wyss; Helen Kim; Dorothy M Morré; D James Morré; James E Simon; Mary Ann Lila; Elsa M Janle; Mario G Ferruzzi Journal: Am J Clin Nutr Date: 2008-02 Impact factor: 7.045
Authors: P Mecocci; G Fanó; S Fulle; U MacGarvey; L Shinobu; M C Polidori; A Cherubini; J Vecchiet; U Senin; M F Beal Journal: Free Radic Biol Med Date: 1999-02 Impact factor: 7.376
Authors: S Maynard; G Keijzers; A-M Hansen; M Osler; D Molbo; L Bendix; P Møller; S Loft; M Moreno-Villanueva; A Bürkle; C P Hvitby; S H Schurman; T Stevnsner; L J Rasmussen; K Avlund; V A Bohr Journal: Acta Physiol (Oxf) Date: 2014-04-23 Impact factor: 6.311