Literature DB >> 23867612

Interleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants.

Diganta Pan1, Arpita Das, Wendy Lala, Carys S Kenway-Lynch, David X Liu, Ronald S Veazey, Bapi Pahar.   

Abstract

Interleukin-10 (IL-10) is an important immunomodulatory cytokine that plays an obligate role in regulating inflammatory responses. Here we demonstrated the role of IL-10 in regulating crypts length and breadth as well as maintaining the survival of epithelial cells using rhesus colon explant cultures. Anti-IL-10 antibody treatment of colon explant cultures induced increased production of inflammatory cytokines/molecules like IFNγ, TNFα, CD107a and perforin as well as increased epithelial cell apoptosis compared to media controls tested. Our results suggest that IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNγ and TNFα cytokine production.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AC-3; Apoptosis; Colon; Cytokine; EC; Epithelial cell; HIV; IL-10; JAK1; MAb; RM; SCID; SIV; T-helper 1; Th1; Tyk2; active caspase-3; epithelial cells; human immunodeficiency virus; interleukin-10; janus kinase 1; monoclonal antibody; rIL-10; recombinant IL-10; rhesus macaque; severe combined immunodeficiency; simian immunodeficiency virus; tyrosine kinase 2

Mesh：

Substances：

Year:  2013        PMID： 23867612      PMCID： PMC3770771          DOI： 10.1016/j.cyto.2013.06.312

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  20 in total

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2.  Transforming growth factor-β1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants.

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