| Literature DB >> 23867167 |
Manato Suda1, Miyuki Katoh, Kazuya Toda, Kiriko Matsumoto, Koichiro Kawaguchi, Sei-ichi Kawahara, Yasunao Hattori, Hiroshi Fujii, Hidefumi Makabe.
Abstract
Synthesis of procyanidin B2 and B3 gallate derivatives, 3-O-gallate, 3"-O-gallate, and 3,3"-di-O-gallate, were synthesized using equimolar condensation mediated by Yb(OTf)3. Synthesized compounds showed significant antitumor effects against human prostate PC-3 cell lines. Their activities were weaker than well-known EGCG and prodelphinidin B3.Entities:
Keywords: Antitumor; Condensation; Lewis acid; Polyphenol; Procyanidin gallate
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Year: 2013 PMID： 23867167 DOI： 10.1016/j.bmcl.2013.06.061
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823