Literature DB >> 23867156

miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor.

Bo Long1, Kun Wang1, Na Li1, Iram Murtaza2, Jing-Ying Xiao1, Yuan-Yuan Fan1, Cui-Yun Liu1, Wen-Hui Li3, Zheng Cheng3, PeiFeng Li4.   

Abstract

Mitochondria are dynamic organelles that constantly undergo fission and fusion. The balance between fission and fusion determines the fate of the cell. In this study, we show that mitochondrial fission factor (MFF) is upregulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Knockdown of MFF attenuated hydrogen peroxide- and I/R injury-induced cardiomyocyte apoptosis and myocardial infarction. We found that MFF is a direct target of miR-761, and miR-761 inhibits mitochondrial fission and cardiomyocyte apoptosis by repressing MFF. This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and MFF. Modulation of their levels may provide a new approach for tackling apoptosis and myocardial infarction.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; Free radicals; Hydrogen peroxide; Ischemia/reperfusion; MFF; MicroRNAs; Mitochondrial fission

Mesh：

Substances：

Year:  2013        PMID： 23867156      PMCID： PMC4397917          DOI： 10.1016/j.freeradbiomed.2013.07.009

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


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